Ceranib 1

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Cat.No. 4448 - Ceranib 1 | C26H21NO3 | CAS No. 328076-61-5
Description: Ceramidase inhibitor; antiproliferative
Chemical Name: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity

Ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.

Technical Data

M. Wt 395.45
Formula C26H21NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 328076-61-5
PubChem ID 5761166
InChI Key OJMCCNQNCSCAJV-RVDMUPIBSA-N
Smiles O=C2C(C(/C=C/C4=CC=C(OC)C=C4)=O)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 395.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Draper et al (2011) Discovery and evaluation of inhibitors of human ceramidase. Mol. Cancer Ther. 10 2052 PMID: 21885864


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Keywords: Ceranib 1, Ceranib 1 supplier, Ceranib1, supplier, ceramidase, inhibitors, inhibits, antiproliferative, ceramides, accumulation, sphingosine, 1, phosphate, s1p, Ceramidases, 4448, Tocris Bioscience

1 Citation for Ceranib 1

Citations are publications that use Tocris products. Selected citations for Ceranib 1 include:

Davis (2015) The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Sci Rep 12 847 PMID: 26510981


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Literature in this Area

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