Ceranib 1

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Description: Ceramidase inhibitor; antiproliferative
Chemical Name: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Ceranib 1

Ceranib 1 is a ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.

Technical Data for Ceranib 1

M. Wt 395.45
Formula C26H21NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 328076-61-5
PubChem ID 5761166
Smiles O=C2C(C(/C=C/C4=CC=C(OC)C=C4)=O)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ceranib 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.55 100

Preparing Stock Solutions for Ceranib 1

The following data is based on the product molecular weight 395.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References for Ceranib 1

References are publications that support the biological activity of the product.

Draper et al (2011) Discovery and evaluation of inhibitors of human ceramidase. Mol. Cancer Ther. 10 2052 PMID: 21885864

If you know of a relevant reference for Ceranib 1, please let us know.

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Keywords: Ceranib 1, Ceranib 1 supplier, Ceranib1, supplier, ceramidase, inhibitors, inhibits, antiproliferative, ceramides, accumulation, sphingosine, 1, phosphate, s1p, Ceramidases, 4448, Tocris Bioscience

1 Citation for Ceranib 1

Citations are publications that use Tocris products. Selected citations for Ceranib 1 include:

Davis (2015) The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Sci Rep 12 847 PMID: 26510981

Do you know of a great paper that uses Ceranib 1 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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