Ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||3.95||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 395.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.53 mL||12.64 mL||25.29 mL|
|5 mM||0.51 mL||2.53 mL||5.06 mL|
|10 mM||0.25 mL||1.26 mL||2.53 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Draper et al (2011) Discovery and evaluation of inhibitors of human ceramidase. Mol. Cancer Ther. 10 2052 PMID: 21885864
If you know of a relevant reference for Ceranib 1, please let us know.
View Related Products by Product Action
Keywords: Ceranib 1, supplier, Ceranib1, supplier, ceramidase, inhibitors, inhibits, antiproliferative, ceramides, accumulation, sphingosine, 1, phosphate, s1p, Ceramidases, Tocris Bioscience
1 Citation for Ceranib 1
Citations are publications that use Tocris products. Selected citations for Ceranib 1 include:
Davis (2015) The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Sci Rep 12 847 PMID: 26510981
Do you know of a great paper that uses Ceranib 1 from Tocris? If so please let us know.
Literature in this Area
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.