Ceranib 1

Pricing Availability Delivery Time Qty
Cat.No. 4448 - Ceranib 1 | C26H21NO3 | CAS No. 328076-61-5
Description: Ceramidase inhibitor; antiproliferative
Chemical Name: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.

Technical Data

M. Wt 395.45
Formula C26H21NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 328076-61-5
PubChem ID 5761166
InChI Key OJMCCNQNCSCAJV-RVDMUPIBSA-N
Smiles O=C2C(C(/C=C/C4=CC=C(OC)C=C4)=O)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.55 100
ethanol 3.95 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 395.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Draper et al (2011) Discovery and evaluation of inhibitors of human ceramidase. Mol. Cancer Ther. 10 2052 PMID: 21885864


If you know of a relevant reference for Ceranib 1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Ceramidase Inhibitors

Keywords: Ceranib 1, supplier, Ceranib1, supplier, ceramidase, inhibitors, inhibits, antiproliferative, ceramides, accumulation, sphingosine, 1, phosphate, s1p, Ceramidases, Tocris Bioscience

1 Citation for Ceranib 1

Citations are publications that use Tocris products. Selected citations for Ceranib 1 include:

Davis (2015) The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Sci Rep 12 847 PMID: 26510981


Do you know of a great paper that uses Ceranib 1 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Ceranib 1

Protocols

TODO: Add Protocols