Ceranib 1

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Cat.No. 4448 - Ceranib 1 | C26H21NO3 | CAS No. 328076-61-5
Description: Ceramidase inhibitor; antiproliferative
Chemical Name: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.

Technical Data

M. Wt 395.45
Formula C26H21NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 328076-61-5
PubChem ID 5761166
Smiles O=C2C(C(/C=C/C4=CC=C(OC)C=C4)=O)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.55 100
ethanol 3.95 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 395.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Draper et al (2011) Discovery and evaluation of inhibitors of human ceramidase. Mol. Cancer Ther. 10 2052 PMID: 21885864

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1 Citation for Ceranib 1

Citations are publications that use Tocris products. Selected citations for Ceranib 1 include:

Davis (2015) The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Sci Rep 12 847 PMID: 26510981

Do you know of a great paper that uses Ceranib 1 from Tocris? If so please let us know.

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Ceranib 1


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