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Highly potent and selective S1P1 and S1P5 agonist (EC50 values are 0.027 and 0.33 nM, respectively, in a cAMP assay). Ki values are 0.574, 0.626, 28.7 >5450 and >5630 nM for S1P5, S1P1, S1P4, S1P2, S1P3, respectively. Reduces peripheral lymphocyte count in a mouse EAE model. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.36||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 435.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||22.96 mL||114.79 mL||229.59 mL|
|0.5 mM||4.59 mL||22.96 mL||45.92 mL|
|1 mM||2.3 mL||11.48 mL||22.96 mL|
|5 mM||0.46 mL||2.3 mL||4.59 mL|
References are publications that support the biological activity of the product.
Kurata et al (2017) Discovery of a 1-methyl-3,4-dihydronaphthalene-based sphingosine-1-phosphate (S1P) receptor agonist ceralifimod (ONO-4641). A S1P1 and S1P5 selective agonist for the treatment of autoimmune diseases. J.Med.Chem. 60 9508 PMID: 29120624
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Keywords: Ceralifimod, Ceralifimod supplier, sphingosine-1-phosphate, S1P1, S1P5, highly, potent, selective, agonists, agonism, orally, bioavailable, Sphingosine-1-phosphate, Receptors, 6690, Tocris Bioscience
Citations for Ceralifimod
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