You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Ceralifimod
Ceralifimod is a highly potent and selective S1P1 and S1P5 agonist (EC50 values are 0.027 and 0.33 nM, respectively, in a cAMP assay). Ki values are 0.574, 0.626, 28.7 >5450 and >5630 nM for S1P5, S1P1, S1P4, S1P2, S1P3, respectively. Reduces peripheral lymphocyte count in a mouse EAE model. Orally bioavailable.
Technical Data for Ceralifimod
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ceralifimod
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.36||10 with gentle warming|
Preparing Stock Solutions for Ceralifimod
The following data is based on the product molecular weight 435.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||22.96 mL||114.79 mL||229.59 mL|
|0.5 mM||4.59 mL||22.96 mL||45.92 mL|
|1 mM||2.3 mL||11.48 mL||22.96 mL|
|5 mM||0.46 mL||2.3 mL||4.59 mL|
References for Ceralifimod
References are publications that support the biological activity of the product.
Kurata et al (2017) Discovery of a 1-methyl-3,4-dihydronaphthalene-based sphingosine-1-phosphate (S1P) receptor agonist ceralifimod (ONO-4641). A S1P1 and S1P5 selective agonist for the treatment of autoimmune diseases. J.Med.Chem. 60 9508 PMID: 29120624
If you know of a relevant reference for Ceralifimod, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Ceralifimod, Ceralifimod supplier, sphingosine-1-phosphate, S1P1, S1P5, highly, potent, selective, agonists, agonism, orally, bioavailable, Sphingosine-1-phosphate, Receptors, 6690, Tocris Bioscience
Citations for Ceralifimod
Citations are publications that use Tocris products.
Currently there are no citations for Ceralifimod. Do you know of a great paper that uses Ceralifimod from Tocris? Please let us know.
Reviews for Ceralifimod
There are currently no reviews for this product. Be the first to review Ceralifimod and earn rewards!
Have you used Ceralifimod?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.