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Submit ReviewCeralifimod
Discontinued Product
6690 has been discontinued.
View all Sphingosine-1-Phosphate Receptors products.
Description: Highly potent and selective S1P1 and S1P5 agonist
Chemical Name: 1-[[3,4-Dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-3-azetidinecarboxylic acid
Purity: ≥95% (HPLC)
Biological Activity for Ceralifimod
Ceralifimod is a highly potent and selective S1P1 and S1P5 agonist (EC50 values are 0.027 and 0.33 nM, respectively, in a cAMP assay). Ki values are 0.574, 0.626, 28.7 >5450 and >5630 nM for S1P5, S1P1, S1P4, S1P2, S1P3, respectively. Reduces peripheral lymphocyte count in a mouse EAE model. Orally bioavailable.
Technical Data for Ceralifimod
| M. Wt | 435.56 |
| Formula | C27H33NO4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 891859-12-4 |
| PubChem ID | 11502996 |
| InChI Key | QDDQIPUKAXBMBX-UHFFFAOYSA-N |
| Smiles | CCCC1=CC(OC)=C(C=C1)COC2=CC=C3C(C)=C(CCC3=C2)CN4CC(C(O)=O)C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ceralifimod
References for Ceralifimod
References are publications that support the biological activity of the product.
Kurata et al (2017) Discovery of a 1-methyl-3,4-dihydronaphthalene-based sphingosine-1-phosphate (S1P) receptor agonist ceralifimod (ONO-4641). A S1P1 and S1P5 selective agonist for the treatment of autoimmune diseases. J.Med.Chem. 60 9508 PMID: 29120624
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Keywords: Ceralifimod, Ceralifimod supplier, sphingosine-1-phosphate, S1P1, S1P5, highly, potent, selective, agonists, agonism, orally, bioavailable, Sphingosine-1-phosphate, Receptors, 6690, Tocris Bioscience
Citations for Ceralifimod
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Currently there are no citations for Ceralifimod.
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