CDP 840 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3936 - CDP 840 hydrochloride | C25H27NO2.HCl | CAS No. 162542-90-7
Description: Potent and selective PDE4 inhibitor
Chemical Name: 4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 12 nM for native PDE4). Competitively inhibits all PDE4 isoenzymes (IC50 values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast).

Technical Data

M. Wt 409.95
Formula C25H27NO2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 162542-90-7
PubChem ID 89809670
InChI Key DQXFOLCDYKWSIT-GNAFDRTKSA-N
Smiles COC1=C(OC2CCCC2)C=C([C@@H]([C@]4=CC=CC=C4)CC3=CC=NC=C3)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 409.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.2 mL 24.39 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Hughes et al (1996) The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br.J.Pharmacol. 118 1183 PMID: 8818342

Perry et al (1998) CDP840: a novel inhibitor of PDE-4. Cell Biochem.Biophys. 29 113 PMID: 9631241

Cooper et al (1999) A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo. Br.J.Pharmacol. 126 1863 PMID: 10372831


If you know of a relevant reference for CDP 840 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phosphodiesterase Inhibitors

Keywords: CDP840 hydrochloride phosphodiesterases pde4 isoenzymes inhibitors inhibits potent selective Phosphodiesterases

Citations for CDP 840 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for CDP 840 hydrochloride. Do you know of a great paper that uses CDP 840 hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pathways for CDP 840 hydrochloride

Protocols

TODO: Add Protocols