CDP 840 hydrochloride

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Cat.No. 3936 - CDP 840 hydrochloride | C25H27NO2.HCl | CAS No. 162542-90-7
Description: Potent and selective PDE4 inhibitor
Chemical Name: 4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 12 nM for native PDE4). Competitively inhibits all PDE4 isoenzymes (IC50 values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast).

Technical Data

M. Wt 409.95
Formula C25H27NO2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 162542-90-7
PubChem ID 89809670
InChI Key DQXFOLCDYKWSIT-GNAFDRTKSA-N
Smiles COC1=C(OC2CCCC2)C=C([C@@H]([C@]4=CC=CC=C4)CC3=CC=NC=C3)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 409.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.2 mL 24.39 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hughes et al (1996) The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br.J.Pharmacol. 118 1183 PMID: 8818342

Perry et al (1998) CDP840: a novel inhibitor of PDE-4. Cell Biochem.Biophys. 29 113 PMID: 9631241

Cooper et al (1999) A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo. Br.J.Pharmacol. 126 1863 PMID: 10372831


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