CD38 inhibitor 78c

Pricing Availability   Qty
Cat.No. 6391 - CD38 inhibitor 78cCD38 inhibitor 78cCD38 inhibitor 78cCD38 inhibitor 78c | C22H27N3O3S | CAS No. 1700637-55-3
Description: Potent CD38 inhibitor; active in vivo
Chemical Name: 4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-quinolinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Potent CD38 (ADP ribosyl cyclase/hydrolase) inhibitor (IC50 values are 1.9 and 7.3 nM at mouse and human CD38, respectively). Catalyzes breakdown of NAD to nicotinamide and ADPR, and hydrolyzes NAADP to adenosine-5'-O-diphosphoribose phosphate. Elevates NAD+ levels >5-fold in liver and >1.2-fold in muscle of diet-induced obese (DIO) C57Bl6 mice. Also prevents age-related NAD+ decline in mice. Improves glucose intolerance, cardiac function and improves physiological and metabolic parameters in old mice.

Technical Data

M. Wt 413.54
Formula C22H27N3O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1700637-55-3
PubChem ID 118736856
InChI Key VJQALSOBHVEJQM-QAQDUYKDSA-N
Smiles COCCO[C@H]1CC[C@H](NC2=CC(N(C3=CC=C(C4=CN=CS4)C=C23)C)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 413.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.09 mL 24.18 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Tarrago et al (2018) A potent and specific CD38 inhibitor ameliorates age-related metabolic dysfunction by reversing tissue NAD+ decline. Cell Metab. 27 1081 PMID: 29719225

Haffner et al (2015) Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors. J.Med.Chem. 58 3548 PMID: 25828863


If you know of a relevant reference for CD38 inhibitor 78c, please let us know.

View Related Products by Target

Keywords: CD38 inhibitor 78c CD38 inhibitor 78c CD38 inhibitor 78c CD38 inhibitor 78c, CD38 inhibitor 78c CD38 inhibitor 78c CD38 inhibitor 78c CD38 inhibitor 78c supplier, CD38, inhibitor, 78c, Potent, inhibitors, inhibits, ADP, ribosyl, cyclases, CD157, hydrolases, Other, Hydrolases, 6391, Tocris Bioscience

Citations for CD38 inhibitor 78c

Citations are publications that use Tocris products.

Currently there are no citations for CD38 inhibitor 78c. Do you know of a great paper that uses CD38 inhibitor 78c from Tocris? Please let us know.

Reviews for CD38 inhibitor 78c

There are currently no reviews for this product. Be the first to review CD38 inhibitor 78c and earn rewards!

Have you used CD38 inhibitor 78c?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells