CCK Octapeptide, sulfated
Endogenous C-terminal octapeptide of CCK found in the central nervous system and gastrointestinal tract.
Non-sulfated Peptide also available.
(Modifications: Tyr-2 = SO3H, Phe-8 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.50 mg/ml in PBS (pH 7.4) with sonication|
References are publications that support the biological activity of the product.
Beinfel (1997) CCK biosynthesis and processing: recent progress and future challenges. Life Sci. 61 2359 PMID: 9399627
Gaw et al (1995) Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat. Br.J.Pharmacol. 115 660 PMID: 7582487
Heinemann et al (1995) Mediation by CCKB receptors of the CCK-evoked hyperaemia in rat gastric mucosa. Br.J.Pharmacol. 116 2274 PMID: 8564259
Wank (1998) G-protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family. Am.J.Physiol. 274 G607 PMID: 9575840
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Keywords: CCK Octapeptide, sulfated, CCK Octapeptide, sulfated supplier, C-terminal, octapeptide, CCK, Cholecystokinin, Non-Selective, Receptors, agonists, CCK-8, CCK8, Octapeptide,, sulfated, Non-selective, 1166, Tocris Bioscience
6 Citations for CCK Octapeptide, sulfated
Citations are publications that use Tocris products. Selected citations for CCK Octapeptide, sulfated include:
Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278 PMID: 24385417
Reidelberger et al (2014) Role of capsaicin-sensitive peripheral sensory neurons in anorexic responses to intravenous infusions of cholecystokinin, peptide YY-(3-36), and glucagon-like peptide-1 in rats. Am J Physiol Endocrinol Metab 307 E619 PMID: 25117406
Gamble et al (2013) Plasminogen activator inhibitor (PAI)-1 suppresses inhibition of gastric emptying by cholecystokinin (CCK) in mice. J Neuroendocrinol 185 41518 PMID: 23816469
Caquineau et al (2010) Effects of cholecystokinin in the supraoptic nucleus and paraventricular nucleus are negatively modulated by leptin in 24-h fasted lean male rats. Autophagy 22 446 PMID: 20163516
D'Agostino et al (2016) Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. Regul Pept 5 PMID: 26974347
Hisadome et al (2011) CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes 60 2701 PMID: 21885869
Do you know of a great paper that uses CCK Octapeptide, sulfated from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.