CCK Octapeptide, sulfated

Pricing Availability   Qty
Description: C-terminal octapeptide of CCK
Alternative Names: Cholecystokinin Octapeptide,sulfated,CCK-8
Purity: ≥95% (HPLC)
Citations (8)
Reviews (1)
Literature (1)

Biological Activity for CCK Octapeptide, sulfated

CCK Octapeptide, sulfated is an endogenous C-terminal octapeptide of CCK found in the central nervous system and gastrointestinal tract.

Non-sulfated Peptide also available.

Technical Data for CCK Octapeptide, sulfated

M. Wt 1142.2
Formula C49H62N10O16S3

(Modifications: Tyr-2 = SO3H, Phe-8 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 25126-32-3
PubChem ID 9833444
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(OS(O)(=O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CCK Octapeptide, sulfated

Solubility Soluble to 0.50 mg/ml in PBS (pH 7.4) with sonication

Product Datasheets for CCK Octapeptide, sulfated

Certificate of Analysis / Product Datasheet
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References for CCK Octapeptide, sulfated

References are publications that support the biological activity of the product.

Beinfel (1997) CCK biosynthesis and processing: recent progress and future challenges. Life Sci. 61 2359 PMID: 9399627

Gaw et al (1995) Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat. Br.J.Pharmacol. 115 660 PMID: 7582487

Heinemann et al (1995) Mediation by CCKB receptors of the CCK-evoked hyperaemia in rat gastric mucosa. Br.J.Pharmacol. 116 2274 PMID: 8564259

Wank (1998) G-protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family. Am.J.Physiol. 274 G607 PMID: 9575840

If you know of a relevant reference for CCK Octapeptide, sulfated, please let us know.

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View all Non-selective CCK Agonists

Keywords: CCK Octapeptide, sulfated, CCK Octapeptide, sulfated supplier, C-terminal, octapeptide, CCK, Cholecystokinin, Non-Selective, Receptors, agonists, CCK-8, CCK8, Octapeptide,, sulfated, Non-selective, 1166, Tocris Bioscience

8 Citations for CCK Octapeptide, sulfated

Citations are publications that use Tocris products. Selected citations for CCK Octapeptide, sulfated include:

Hisadome et al (2011) CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes 60 2701 PMID: 21885869

Wang et al (2019) TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons. JCI Insight 4 PMID: 30843875

Wang et al (2019) A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding. Nat Commun 10 2769 PMID: 31235690

Caquineau et al (2010) Effects of cholecystokinin in the supraoptic nucleus and paraventricular nucleus are negatively modulated by leptin in 24-h fasted lean male rats. Autophagy 22 446 PMID: 20163516

Do you know of a great paper that uses CCK Octapeptide, sulfated from Tocris? Please let us know.

Reviews for CCK Octapeptide, sulfated

Average Rating: 4 (Based on 1 Review.)

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Applied to colon tissue.
By John Broad on 01/05/2018
Assay Type: In Vitro
Species: Human

1uM CCK contracts GI smooth muscle

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.