CCK Octapeptide, sulfated

Pricing Availability Delivery Time Qty
Cat.No. 1166 - CCK Octapeptide, sulfated | Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 | CAS No. 25126-32-3
Description: C-terminal octapeptide of CCK
Alternative Names: Cholecystokinin Octapeptide, sulfated, CCK-8
Datasheet
Citations (6)
Reviews (1)
Literature

Biological Activity

Endogenous C-terminal octapeptide of CCK found in the central nervous system and gastrointestinal tract.

Non-sulfated Peptide also available.

Technical Data

M. Wt 1142.2
Formula C49H62N10O16S3
Sequence DYMGWMDF

(Modifications: Tyr-2 = SO3H, Phe-8 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 25126-32-3
PubChem ID 9833444
InChI Key IZTQOLKUZKXIRV-YRVFCXMDSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(OS(O)(=O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 0.50 mg/ml in PBS (pH 7.4) with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 1142.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.88 mL 4.38 mL 8.76 mL
5 mM 0.18 mL 0.88 mL 1.75 mL
10 mM 0.09 mL 0.44 mL 0.88 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Beinfel (1997) CCK biosynthesis and processing: recent progress and future challenges. Life Sci. 61 2359 PMID: 9399627

Gaw et al (1995) Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat. Br.J.Pharmacol. 115 660 PMID: 7582487

Heinemann et al (1995) Mediation by CCKB receptors of the CCK-evoked hyperaemia in rat gastric mucosa. Br.J.Pharmacol. 116 2274 PMID: 8564259

Wank (1998) G-protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family. Am.J.Physiol. 274 G607 PMID: 9575840


If you know of a relevant reference for CCK Octapeptide, sulfated, please let us know.

View Related Products by Product Action

View all Non-selective CCK Agonists

Keywords: CCK Octapeptide, sulfated, CCK Octapeptide, sulfated supplier, C-terminal, octapeptide, CCK, Cholecystokinin, Non-Selective, Receptors, agonists, CCK-8, CCK8, Octapeptide,, sulfated, Non-selective, 1166, Tocris Bioscience

6 Citations for CCK Octapeptide, sulfated

Citations are publications that use Tocris products. Selected citations for CCK Octapeptide, sulfated include:

D'Agostino et al (2016) Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. Regul Pept 5 PMID: 26974347

Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278 PMID: 24385417

Reidelberger et al (2014) Role of capsaicin-sensitive peripheral sensory neurons in anorexic responses to intravenous infusions of cholecystokinin, peptide YY-(3-36), and glucagon-like peptide-1 in rats. Am J Physiol Endocrinol Metab 307 E619 PMID: 25117406

Gamble et al (2013) Plasminogen activator inhibitor (PAI)-1 suppresses inhibition of gastric emptying by cholecystokinin (CCK) in mice. J Neuroendocrinol 185 41518 PMID: 23816469

Hisadome et al (2011) CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes 60 2701 PMID: 21885869

Caquineau et al (2010) Effects of cholecystokinin in the supraoptic nucleus and paraventricular nucleus are negatively modulated by leptin in 24-h fasted lean male rats. Autophagy 22 446 PMID: 20163516


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Reviews for CCK Octapeptide, sulfated

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Applied to colon tissue
By John Broad on 01/05/2018
Assay Type: In Vitro
Species: Human

1uM CCK contracts GI smooth muscle

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