CCK Octapeptide, sulfated
Endogenous C-terminal octapeptide of CCK found in the central nervous system and gastrointestinal tract. Non-sulfated CCK Octapeptide (Cat. No. 1150) also available.
(Modifications: Tyr-2 = SO3H, Phe-8 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.50 mg/ml in PBS (pH 7.4) with sonication|
Preparing Stock Solutions
The following data is based on the product molecular weight 1142.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.88 mL||4.38 mL||8.76 mL|
|5 mM||0.18 mL||0.88 mL||1.75 mL|
|10 mM||0.09 mL||0.44 mL||0.88 mL|
|50 mM||0.02 mL||0.09 mL||0.18 mL|
References are publications that support the products' biological activity.
Beinfel (1997) CCK biosynthesis and processing: recent progress and future challenges. Life Sci. 61 2359 PMID: 9399627
Gaw et al (1995) Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat. Br.J.Pharmacol. 115 660 PMID: 7582487
Heinemann et al (1995) Mediation by CCKB receptors of the CCK-evoked hyperaemia in rat gastric mucosa. Br.J.Pharmacol. 116 2274 PMID: 8564259
Wank (1998) G-protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family. Am.J.Physiol. 274 G607 PMID: 9575840
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5 Citations for CCK Octapeptide, sulfated
Citations are publications that use Tocris products. Selected citations for CCK Octapeptide, sulfated include:
Gamble et al (2013) Plasminogen activator inhibitor (PAI)-1 suppresses inhibition of gastric emptying by cholecystokinin (CCK) in mice. J Neuroendocrinol 185 41518 PMID: 23816469
D'Agostino et al (2016) Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. Regul Pept 5 PMID: 26974347
Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278 PMID: 24385417
Reidelberger et al (2014) Role of capsaicin-sensitive peripheral sensory neurons in anorexic responses to intravenous infusions of cholecystokinin, peptide YY-(3-36), and glucagon-like peptide-1 in rats. Am J Physiol Endocrinol Metab 307 E619 PMID: 25117406
Caquineau et al (2010) Effects of cholecystokinin in the supraoptic nucleus and paraventricular nucleus are negatively modulated by leptin in 24-h fasted lean male rats. Autophagy 22 446 PMID: 20163516
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