CCF 642

Discontinued Product

CCF 642 (Cat. No. 6063) has been withdrawn from sale for commercial reasons.
Description: Protein disulfide isomerase (PDI) inhibitor
Chemical Name: 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for CCF 642

CCF 642 is a protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro (submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.

Technical Data for CCF 642

M. Wt 378.45
Formula C15H10N2O4S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 346640-08-2
PubChem ID 1820764
Smiles COC1=CC=C(N2C(S/C(C2=O)=C/C3=CC=C([N+]([O-])=O)S3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CCF 642

References are publications that support the biological activity of the product.

Vatolin et al (2016) Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma. Cancer Res. 76 3340 PMID: 27197150

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Keywords: CCF 642, CCF 642 supplier, CCF642, protein, disulfide, isomerases, PDI, inhibitors, inhibits, cancer, multiple, myeloma, cells, Protein, Disulfide, Isomerase, 6063, Tocris Bioscience

Citations for CCF 642

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Currently there are no citations for CCF 642.

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Literature in this Area

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Gut Hormones Poster

Gut Hormones Poster

The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.