CCF 642

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Cat.No. 6063 - CCF 642 | C15H10N2O4S3 | CAS No. 346640-08-2
Description: Protein disulfide isomerase (PDI) inhibitor
Chemical Name: 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro (submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.

Technical Data

M. Wt 378.45
Formula C15H10N2O4S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 346640-08-2
PubChem ID 1820764
InChI Key SPYIETQLOVDJCF-XYOKQWHBSA-N
Smiles COC1=CC=C(N2C(S/C(C2=O)=C/C3=CC=C([N+]([O-])=O)S3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.57 20

Preparing Stock Solutions

The following data is based on the product molecular weight 378.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.42 mL
5 mM 0.53 mL 2.64 mL 5.28 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Vatolin et al (2016) Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma. Cancer Res. 76 3340 PMID: 27197150


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Citations for CCF 642

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