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CCF 642 is a protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro (submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 378.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.21 mL||66.06 mL||132.12 mL|
|1 mM||2.64 mL||13.21 mL||26.42 mL|
|2 mM||1.32 mL||6.61 mL||13.21 mL|
|10 mM||0.26 mL||1.32 mL||2.64 mL|
References are publications that support the biological activity of the product.
Vatolin et al (2016) Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma. Cancer Res. 76 3340 PMID: 27197150
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Keywords: CCF 642, CCF 642 supplier, CCF642, protein, disulfide, isomerases, PDI, inhibitors, inhibits, cancer, multiple, myeloma, cells, Protein, Disulfide, Isomerase, 6063, Tocris Bioscience
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