CCF 642

Pricing Availability   Qty
Description: Protein disulfide isomerase (PDI) inhibitor
Chemical Name: 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for CCF 642

CCF 642 is a protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro (submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.

Technical Data for CCF 642

M. Wt 378.45
Formula C15H10N2O4S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 346640-08-2
PubChem ID 1820764
Smiles COC1=CC=C(N2C(S/C(C2=O)=C/C3=CC=C([N+]([O-])=O)S3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CCF 642

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.57 20

Preparing Stock Solutions for CCF 642

The following data is based on the product molecular weight 378.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.21 mL 66.06 mL 132.12 mL
1 mM 2.64 mL 13.21 mL 26.42 mL
2 mM 1.32 mL 6.61 mL 13.21 mL
10 mM 0.26 mL 1.32 mL 2.64 mL

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References for CCF 642

References are publications that support the biological activity of the product.

Vatolin et al (2016) Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma. Cancer Res. 76 3340 PMID: 27197150

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Citations for CCF 642

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