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Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 336.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.97 mL||14.86 mL||29.73 mL|
|5 mM||0.59 mL||2.97 mL||5.95 mL|
|10 mM||0.3 mL||1.49 mL||2.97 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
References are publications that support the biological activity of the product.
Mullarky et al (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc.Natl.Acad.Sci.U.S.A. 113 1778 PMID: 26831078
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Keywords: CBR 5884, CBR 5884 supplier, CBR5884, PHGDH, 3-phosphoglycerate, dehydrogenases, inhibitors, inhibits, serine, synthesis, cancer, Other, Dehydrogenases, 5836, Tocris Bioscience
2 Citations for CBR 5884
Citations are publications that use Tocris products. Selected citations for CBR 5884 include:
Sen et al (2018) EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. Mol Carcinog 57 1342 PMID: 29873416
Nigdelioglu et al (2016) Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem 291 27239 PMID: 27836973
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Literature in this Area
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