CBR 5884

Pricing Availability Delivery Time Qty
Cat.No. 5836 - CBR 5884 | C14H12N2O4S2 | CAS No. 681159-27-3
Description: 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor
Chemical Name: Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

Technical Data

M. Wt 336.39
Formula C14H12N2O4S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 681159-27-3
PubChem ID 4674993
InChI Key QBVIRPJBDIZKBC-UHFFFAOYSA-N
Smiles CCOC(C1=C(C(SC#N)=C(S1)NC(C2=CC=CO2)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 336.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.86 mL 29.73 mL
5 mM 0.59 mL 2.97 mL 5.95 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mullarky et al (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc.Natl.Acad.Sci.U.S.A. 113 1778 PMID: 26831078


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Keywords: CBR5884 PHGDH 3-phosphoglycerate dehydrogenases inhibitors inhibits serine synthesis cancer Other Dehydrogenases

Citations for CBR 5884

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