CBR 5884

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Description: Phosphoglycerate dehydrogenase (PHGDH) inhibitor
Chemical Name: Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for CBR 5884

CBR 5884 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

Technical Data for CBR 5884

M. Wt 336.39
Formula C14H12N2O4S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 681159-27-3
PubChem ID 4674993
Smiles CCOC(C1=C(C(SC#N)=C(S1)NC(C2=CC=CO2)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CBR 5884

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.64 100

Preparing Stock Solutions for CBR 5884

The following data is based on the product molecular weight 336.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.86 mL 29.73 mL
5 mM 0.59 mL 2.97 mL 5.95 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References for CBR 5884

References are publications that support the biological activity of the product.

Mullarky et al (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc.Natl.Acad.Sci.U.S.A. 113 1778 PMID: 26831078

If you know of a relevant reference for CBR 5884, please let us know.

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Keywords: CBR 5884, CBR 5884 supplier, CBR5884, PHGDH, 3-phosphoglycerate, dehydrogenases, inhibitors, inhibits, serine, synthesis, cancer, Other, Dehydrogenases, 5836, Tocris Bioscience

2 Citations for CBR 5884

Citations are publications that use Tocris products. Selected citations for CBR 5884 include:

Nigdelioglu et al (2016) Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem 291 27239 PMID: 27836973

Sen et al (2018) EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. Mol Carcinog 57 1342 PMID: 29873416

Do you know of a great paper that uses CBR 5884 from Tocris? Please let us know.

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