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Biological Activity for CBR 5884
CBR 5884 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.
Technical Data for CBR 5884
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CBR 5884
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CBR 5884
The following data is based on the product molecular weight 336.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.97 mL||14.86 mL||29.73 mL|
|5 mM||0.59 mL||2.97 mL||5.95 mL|
|10 mM||0.3 mL||1.49 mL||2.97 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
References for CBR 5884
References are publications that support the biological activity of the product.
Mullarky et al (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc.Natl.Acad.Sci.U.S.A. 113 1778 PMID: 26831078
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Keywords: CBR 5884, CBR 5884 supplier, CBR5884, PHGDH, 3-phosphoglycerate, dehydrogenases, inhibitors, inhibits, serine, synthesis, cancer, Other, Dehydrogenases, 5836, Tocris Bioscience
2 Citations for CBR 5884
Citations are publications that use Tocris products. Selected citations for CBR 5884 include:
Nigdelioglu et al (2016) Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem 291 27239 PMID: 27836973
Sen et al (2018) EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. Mol Carcinog 57 1342 PMID: 29873416
Do you know of a great paper that uses CBR 5884 from Tocris? Please let us know.
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