CBR 5884

Discontinued Product

CBR 5884 (Cat. No. 5836) has been withdrawn from sale for commercial reasons.
Description: Phosphoglycerate dehydrogenase (PHGDH) inhibitor
Chemical Name: Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for CBR 5884

CBR 5884 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

Technical Data for CBR 5884

M. Wt 336.39
Formula C14H12N2O4S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 681159-27-3
PubChem ID 4674993
Smiles CCOC(C1=C(C(SC#N)=C(S1)NC(C2=CC=CO2)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CBR 5884

References are publications that support the biological activity of the product.

Mullarky et al (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc.Natl.Acad.Sci.U.S.A. 113 1778 PMID: 26831078

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Keywords: CBR 5884, CBR 5884 supplier, CBR5884, PHGDH, 3-phosphoglycerate, dehydrogenases, inhibitors, inhibits, serine, synthesis, cancer, Other, Dehydrogenases, 5836, Tocris Bioscience

2 Citations for CBR 5884

Citations are publications that use Tocris products. Selected citations for CBR 5884 include:

Nigdelioglu et al (2016) Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem 291 27239 PMID: 27836973

Sen et al (2018) EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. Mol Carcinog 57 1342 PMID: 29873416

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.