Castanospermine

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Cat.No. 0759 - Castanospermine | C8H15NO4 | CAS No. 79831-76-8
Description: Glucosidases α and β inhibitor
Chemical Name: [1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

Compound Libraries

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Technical Data

M. Wt 189.21
Formula C8H15NO4
Storage Store at RT
CAS Number 79831-76-8
PubChem ID 54445
InChI Key JDVVGAQPNNXQDW-TVNFTVLESA-N
Smiles [H][C@]12[C@@H](O)CCN1C[C@H](O)[C@@H](O)[C@@H]2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.46 50
water 18.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 189.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.29 mL 26.43 mL 52.85 mL
5 mM 1.06 mL 5.29 mL 10.57 mL
10 mM 0.53 mL 2.64 mL 5.29 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Gruters et al (1987) Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 330 74 PMID: 2959866

Saul et al (1984) Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases. Arch.Biochem.Biophys. 230 668 PMID: 6424575

Welker et al (1987) Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc.Natl.Acad.Sci.U.S.A. 84 8120 PMID: 2825177


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Keywords: Castanospermine, Castanospermine supplier, β-glucosidases, beta-glucosidases, b-glucosidase, inhibitors, inhibits, a-Glucosidase, α-glucosidase, alpha-glucosidase, Glycosylases, Carbohydrate, Metabolism, 0759, Tocris Bioscience

1 Citation for Castanospermine

Citations are publications that use Tocris products. Selected citations for Castanospermine include:

Nacev et al (2011) The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem 286 44045 PMID: 22025615


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Literature in this Area

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