Pricing Availability   Qty
Description: Glucosidases α and β inhibitor
Chemical Name: [1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol
Citations (1)

Biological Activity for Castanospermine

Castanospermine is a potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

Technical Data for Castanospermine

M. Wt 189.21
Formula C8H15NO4
Storage Store at RT
CAS Number 79831-76-8
PubChem ID 54445
Smiles [H][C@]12[C@@H](O)CCN1C[C@H](O)[C@@H](O)[C@@H]2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Castanospermine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.46 50
water 18.92 100

Preparing Stock Solutions for Castanospermine

The following data is based on the product molecular weight 189.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.29 mL 26.43 mL 52.85 mL
5 mM 1.06 mL 5.29 mL 10.57 mL
10 mM 0.53 mL 2.64 mL 5.29 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Castanospermine

Certificate of Analysis / Product Datasheet
Select another batch:

References for Castanospermine

References are publications that support the biological activity of the product.

Gruters et al (1987) Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 330 74 PMID: 2959866

Saul et al (1984) Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases. Arch.Biochem.Biophys. 230 668 PMID: 6424575

Welker et al (1987) Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc.Natl.Acad.Sci.U.S.A. 84 8120 PMID: 2825177

If you know of a relevant reference for Castanospermine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Glycosylase Inhibitors

Keywords: Castanospermine, Castanospermine supplier, β-glucosidases, beta-glucosidases, b-glucosidase, inhibitors, inhibits, a-Glucosidase, α-glucosidase, alpha-glucosidase, Glycosylases, Carbohydrate, Metabolism, 0759, Tocris Bioscience

1 Citation for Castanospermine

Citations are publications that use Tocris products. Selected citations for Castanospermine include:

Nacev et al (2011) The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem 286 44045 PMID: 22025615

Do you know of a great paper that uses Castanospermine from Tocris? Please let us know.

Reviews for Castanospermine

There are currently no reviews for this product. Be the first to review Castanospermine and earn rewards!

Have you used Castanospermine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review