CART (62-76) (rat, human)
Cocaine- and amphetamine-regulated transcript (CART) peptide fragment that inhibits food intake. Attenuates NPY-induced feeding and decreases food intake in food-restricted goldfish, and induces anxiogenic-like effects in elevated plus-maze test in rats. Modulates the activity of striatal noradrenergic, and corticostrial and hypothalamic serotoninergic systems, with no major effect on dopaminergic pathways in rat brain.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in 20% acetonitrile / water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1570.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.64 mL||3.18 mL||6.37 mL|
|5 mM||0.13 mL||0.64 mL||1.27 mL|
|10 mM||0.06 mL||0.32 mL||0.64 mL|
|50 mM||0.01 mL||0.06 mL||0.13 mL|
References are publications that support the products' biological activity.
Volkoff and Peter (2000) Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding. Brain Res. 887 125 PMID: 11134597
Vaarmann and Kask (2001) Cocaine and amphetamine-regulated transcript peptide (CART62-76)-induced changes in regional monoamine levels in rat brain. Neuropeptides 35 292 PMID: 12030814
Colombo et al (2003) Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on release of insulin from isolated rat islets. Pancreas 27 161 PMID: 12883265
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Literature in this Area
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.