CART (62-76) (rat, human)

Pricing Availability Delivery Time Qty
Cat.No. 3339 - CART (62-76) (rat, human) | Tyr-Gly-Gln-Val-Pro-Met-Cys-Asp-Ala-Gly-Glu-Gln-Cys-Ala-Val | CAS No. 210978-19-1
Description: Neuromodulating neuropeptide fragment; inhibits food intake in vivo
Alternative Names: Cocaine and amphetamine-regulated transcript (62-76) (rat, human)

Biological Activity

Cocaine- and amphetamine-regulated transcript (CART) peptide fragment that inhibits food intake. Attenuates NPY-induced feeding and decreases food intake in food-restricted goldfish, and induces anxiogenic-like effects in elevated plus-maze test in rats. Modulates the activity of striatal noradrenergic, and corticostrial and hypothalamic serotoninergic systems, with no major effect on dopaminergic pathways in rat brain.

Technical Data

M. Wt 1570.77
Formula C64H99N17O23S3
Storage Store at -20°C
CAS Number 210978-19-1
PubChem ID 90488836
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 20% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1570.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.64 mL 3.18 mL 6.37 mL
5 mM 0.13 mL 0.64 mL 1.27 mL
10 mM 0.06 mL 0.32 mL 0.64 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Volkoff and Peter (2000) Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding. Brain Res. 887 125 PMID: 11134597

Vaarmann and Kask (2001) Cocaine and amphetamine-regulated transcript peptide (CART62-76)-induced changes in regional monoamine levels in rat brain. Neuropeptides 35 292 PMID: 12030814

Colombo et al (2003) Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on release of insulin from isolated rat islets. Pancreas 27 161 PMID: 12883265

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