Cariporide

Pricing Availability   Qty
Description: Selective NHE1 inhibitor; cardioprotective and antitumor
Alternative Names: HOE 642
Chemical Name: N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for Cariporide

Cariporide is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.

Compound Libraries for Cariporide

Cariporide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Cariporide

M. Wt 283.35
Formula C12H17N3O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 159138-80-4
PubChem ID 151172
InChI Key IWXNYAIICFKCTM-UHFFFAOYSA-N
Smiles CC(C)C1=C(S(C)(=O)=O)C=C(C(NC(N)=N)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cariporide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.34 100

Preparing Stock Solutions for Cariporide

The following data is based on the product molecular weight 283.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.65 mL 35.29 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets for Cariporide

Certificate of Analysis / Product Datasheet
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References for Cariporide

References are publications that support the biological activity of the product.

Scholz et al (1995) Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc.Res. 29 260 PMID: 7736504

Chakrabarti et al (1997) A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). J.Mol.Cell.Cardiol. 29 3169 PMID: 9405190

Teshima et al (2003) Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation 108 2275 PMID: 14568900

Harguindey et al (2013) Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. J.Transl.Med. 11 282 PMID: 24195657


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Keywords: Cariporide, Cariporide supplier, Cariporide, HOE642, selective, sodium, hydrogen, exchanger, NHE1, inhibitors, inhibits, cardioprotective, cardiomyocytes, ischemia, orally, active, Na+/H+, HOE, 642, Exchanger, 5358, Tocris Bioscience

1 Citation for Cariporide

Citations are publications that use Tocris products. Selected citations for Cariporide include:

Alzbeta et al (2022) Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes. Elife 11 PMID: 36107487


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Literature in this Area

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