Pricing Availability   Qty
Description: Selective NHE1 inhibitor; cardioprotective and antitumor
Alternative Names: HOE 642
Chemical Name: N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Cariporide

Cariporide is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.

Compound Libraries for Cariporide

Cariporide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Cariporide

M. Wt 283.35
Formula C12H17N3O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 159138-80-4
PubChem ID 151172
Smiles CC(C)C1=C(S(C)(=O)=O)C=C(C(NC(N)=N)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cariporide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.34 100

Preparing Stock Solutions for Cariporide

The following data is based on the product molecular weight 283.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.65 mL 35.29 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Cariporide

Certificate of Analysis / Product Datasheet
Select another batch:

References for Cariporide

References are publications that support the biological activity of the product.

Scholz et al (1995) Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc.Res. 29 260 PMID: 7736504

Chakrabarti et al (1997) A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). J.Mol.Cell.Cardiol. 29 3169 PMID: 9405190

Teshima et al (2003) Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation 108 2275 PMID: 14568900

Harguindey et al (2013) Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. J.Transl.Med. 11 282 PMID: 24195657

If you know of a relevant reference for Cariporide, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Na+/H+ Exchanger Inhibitors

Keywords: Cariporide, Cariporide supplier, Cariporide, HOE642, selective, sodium, hydrogen, exchanger, NHE1, inhibitors, inhibits, cardioprotective, cardiomyocytes, ischemia, orally, active, Na+/H+, HOE, 642, Exchanger, 5358, Tocris Bioscience

1 Citation for Cariporide

Citations are publications that use Tocris products. Selected citations for Cariporide include:

Alzbeta et al (2022) Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes. Elife 11 PMID: 36107487

Do you know of a great paper that uses Cariporide from Tocris? Please let us know.

Reviews for Cariporide

There are currently no reviews for this product. Be the first to review Cariporide and earn rewards!

Have you used Cariporide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.