Carbenoxolone disodium

Cat. No. 3096 5 Citations Submit a Review Datasheet / COA / SDS

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Description: Gap junction blocker. Also inhibitor of 11 β-hydroxysteroid dehydrogenase

Chemical Name: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium

Purity: ≥98% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Carbenoxolone disodium

Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.

Technical Data for Carbenoxolone disodium

M. Wt	614.72
Formula	C₃₄H₄₈Na₂O₇
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	7421-40-1
PubChem ID	636402
InChI Key	BQENDLAVTKRQMS-SBBGFIFASA-L
Smiles	[Na+].[Na+].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CCC([O-])=O)C(C)(C)[C@]3([H])CC[C@@]12C)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Carbenoxolone disodium

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	61.47	100

Preparing Stock Solutions for Carbenoxolone disodium

The following data is based on the product molecular weight 614.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.13 mL	16.27 mL
5 mM	0.33 mL	1.63 mL	3.25 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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Product Datasheets for Carbenoxolone disodium

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Carbenoxolone disodium

References are publications that support the biological activity of the product.

Jellinck et al (1993) Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J.Steroid Biochem.Mol.Biol. 46 209 PMID: 8664169

Sagar and Larson (2006) Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway. J.Cell.Biochem. 98 1543 PMID: 16552723

If you know of a relevant reference for Carbenoxolone disodium, please let us know.

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