Glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 614.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.63 mL||8.13 mL||16.27 mL|
|5 mM||0.33 mL||1.63 mL||3.25 mL|
|10 mM||0.16 mL||0.81 mL||1.63 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
References are publications that support the products' biological activity.
Jellinck et al (1993) Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J.Steroid Biochem.Mol.Biol. 46 209 PMID: 8664169
Sagar and Larson (2006) Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway. J.Cell.Biochem. 98 1543 PMID: 16552723
If you know of a relevant reference for Carbenoxolone disodium, please let us know.
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Keywords: Carbenoxolone disodium, supplier, Gap, junction, blockers, inhibitors, inhibits, 11, β-hydroxysteroid, beta-hydroxysteroid, dehydrogenase, gap, Connexins, Channels, Dehydrogenases, Gap, Channels, 11b-Hydroxysteroid, Dehydrogenase, Gap, Channels, Tocris Bioscience
1 Citation for Carbenoxolone disodium
Citations are publications that use Tocris products. Selected citations for Carbenoxolone disodium include:
Shuhaibar et al (2015) Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles. Proc Natl Acad Sci U S A 112 5527 PMID: 25775542
Do you know of a great paper that uses Carbenoxolone disodium from Tocris? If so please let us know.
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