Carbenoxolone disodium

Pricing Availability   Qty
Description: Gap junction blocker. Also inhibitor of 11 β-hydroxysteroid dehydrogenase
Chemical Name: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium
Purity: ≥98% (HPLC)
Citations (5)
Literature (1)

Biological Activity for Carbenoxolone disodium

Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.

Technical Data for Carbenoxolone disodium

M. Wt 614.72
Formula C34H48Na2O7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 7421-40-1
PubChem ID 636402
Smiles [Na+].[Na+].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CCC([O-])=O)C(C)(C)[C@]3([H])CC[C@@]12C)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Carbenoxolone disodium

Solvent Max Conc. mg/mL Max Conc. mM
water 61.47 100

Preparing Stock Solutions for Carbenoxolone disodium

The following data is based on the product molecular weight 614.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.13 mL 16.27 mL
5 mM 0.33 mL 1.63 mL 3.25 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Carbenoxolone disodium

Certificate of Analysis / Product Datasheet
Select another batch:

References for Carbenoxolone disodium

References are publications that support the biological activity of the product.

Jellinck et al (1993) Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J.Steroid Biochem.Mol.Biol. 46 209 PMID: 8664169

Sagar and Larson (2006) Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway. J.Cell.Biochem. 98 1543 PMID: 16552723

If you know of a relevant reference for Carbenoxolone disodium, please let us know.

View Related Products by Product Action

View all Gap Channel Blockers

Keywords: Carbenoxolone disodium, Carbenoxolone disodium supplier, Gap, junction, blockers, inhibitors, inhibits, 11, β-hydroxysteroid, beta-hydroxysteroid, dehydrogenase, gap, Connexins, Channels, Dehydrogenases, 11b-Hydroxysteroid, Dehydrogenase, 3096, Tocris Bioscience

5 Citations for Carbenoxolone disodium

Citations are publications that use Tocris products. Selected citations for Carbenoxolone disodium include:

Shuhaibar et al (2015) Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles. Proc Natl Acad Sci U S A 112 5527 PMID: 25775542

Craig and Martin (2012) Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery. Br J Pharmacol 167 527 PMID: 22537086

Ferlauto et al (2018) Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis. Nat Commun 9 992 PMID: 29520006

Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653

Do you know of a great paper that uses Carbenoxolone disodium from Tocris? Please let us know.

Reviews for Carbenoxolone disodium

There are currently no reviews for this product. Be the first to review Carbenoxolone disodium and earn rewards!

Have you used Carbenoxolone disodium?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis