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Biological Activity for CALP3
CALP3 is a cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. Activates phosphodiesterase in the absence of Ca2+ and inhibits Ca2+-mediated cytotoxicity and apoptosis (IC50 = 33 μM).
Technical Data for CALP3
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CALP3
|Solubility||Soluble to 1 mg/ml in water|
References for CALP3
References are publications that support the biological activity of the product.
Manion et al (2000) A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14 1297 PMID: 10877822
Ten Broeke et al (2003) Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur.J.Pharmacol. 476 151 PMID: 12969760
Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676
If you know of a relevant reference for CALP3, please let us know.
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Keywords: CALP3, CALP3 supplier, Cell-permeable, calmodulin, agonists, Ca2+, Binding, Protein, modulators, Calmodulin, Calcium, Signaling, Signalling, Calcium-like, peptide3, peptide, 3, 2321, Tocris Bioscience
1 Citation for CALP3
Citations are publications that use Tocris products. Selected citations for CALP3 include:
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 e2640 PMID: 28252652
Do you know of a great paper that uses CALP3 from Tocris? Please let us know.
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