Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. Activates phosphodiesterase in the absence of Ca2+ and inhibits Ca2+-mediated cytotoxicity and apoptosis (IC50 = 33 μM).
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 881.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.13 mL||5.67 mL||11.35 mL|
|5 mM||0.23 mL||1.13 mL||2.27 mL|
|10 mM||0.11 mL||0.57 mL||1.13 mL|
|50 mM||0.02 mL||0.11 mL||0.23 mL|
References are publications that support the products' biological activity.
Manion et al (2000) A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14 1297 PMID: 10877822
Ten Broeke et al (2003) Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur.J.Pharmacol. 476 151 PMID: 12969760
If you know of a relevant reference for CALP3, please let us know.
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Keywords: CALP3, supplier, Cell-permeable, calmodulin, agonists, Ca2+, Binding, Protein, modulators, Calmodulin, Calcium, Signaling, Signalling, Calcium-like, peptide3, Calcium-like, peptide, 3, Calcium, Binding, Protein, Calcium, Binding, Protein, Tocris Bioscience
1 Citation for CALP3
Citations are publications that use Tocris products. Selected citations for CALP3 include:
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652
Do you know of a great paper that uses CALP3 from Tocris? If so please let us know.
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