CALP3

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Cat.No. 2321 - CALP3 | Val-Lys-Phe-Gly-Val-Gly-Phe-Lys | CAS No. 261969-05-5
Description: Cell-permeable calmodulin agonist
Alternative Names: Calcium-like peptide 3
Datasheet
Citations (1)

Biological Activity

Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. Activates phosphodiesterase in the absence of Ca2+ and inhibits Ca2+-mediated cytotoxicity and apoptosis (IC50 = 33 μM).

Technical Data

M. Wt 881.08
Formula C44H68N10O9
Sequence VKFGVGFK
Storage Desiccate at -20°C
CAS Number 261969-05-5
PubChem ID 10033623
InChI Key OBMFGXCPBIYSPH-FFIZALLVSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 881.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.13 mL 5.67 mL 11.35 mL
5 mM 0.23 mL 1.13 mL 2.27 mL
10 mM 0.11 mL 0.57 mL 1.13 mL
50 mM 0.02 mL 0.11 mL 0.23 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Manion et al (2000) A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14 1297 PMID: 10877822

Ten Broeke et al (2003) Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur.J.Pharmacol. 476 151 PMID: 12969760

Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676 PMID:


If you know of a relevant reference for CALP3, please let us know.

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Keywords: CALP3, supplier, Cell-permeable, calmodulin, agonists, Ca2+, Binding, Protein, modulators, Calmodulin, Calcium, Signaling, Signalling, Calcium-like, peptide3, Calcium-like, peptide, 3, Calcium, Binding, Protein, Modulators, Tocris Bioscience

1 Citation for CALP3

Citations are publications that use Tocris products. Selected citations for CALP3 include:

Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652


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