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Cell-permeable calmodulin (CaM) antagonist that binds to the EF-hand/Ca2+-binding site. CALP2 has been demonstrated to inhibit CaM-dependant phosphodiesterase activity and increase intracellular Ca2+ concentrations by modulating Ca2+-channel activity. CALP2 has also been shown to be a potent activator of alveolar macrophages.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID: 11145661
Ten Broeke et al (2001) Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 15 1831 PMID: 11481245
Ten Broeke et al (2004) Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab.Invest. 84 29 PMID: 14631377
Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676
If you know of a relevant reference for CALP2, please let us know.
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Keywords: CALP2, CALP2 supplier, Cell-permeable, calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Calcium-like, peptide2, peptide, 2, 2319, Tocris Bioscience
4 Citations for CALP2
Citations are publications that use Tocris products. Selected citations for CALP2 include:
Hannanta-anan and Chow (2018) Optogenetic Inhibition of Gαq Protein Signaling Reduces Calcium Oscillation Stochasticity. ACS Synth Biol 7 1488 PMID: 29792810
Spehr et al (2009) Ca2+ -calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ. J Neurosci 29 2125 PMID: 19228965
Heo et al (2015) Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Sci Rep 5 16895 PMID: 26592929
Fernández-Velasco et al (2011) RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. PLoS One 6 e20863 PMID: 21673970
Do you know of a great paper that uses CALP2 from Tocris? Please let us know.
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