CALP2

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Cat.No. 2319 - CALP2 | Val-Lys-Phe-Gly-Val-Gly-Phe-Lys-Val-Met-Val-Phe | CAS No. 261969-04-4
Description: Cell-permeable calmodulin antagonist
Alternative Names: Calcium-like peptide 2
Datasheet
Citations (2)
Reviews

Biological Activity

Cell-permeable calmodulin (CaM) antagonist that binds to the EF-hand/Ca2+-binding site. CALP2 has been demonstrated to inhibit CaM-dependant phosphodiesterase activity and increase intracellular Ca2+ concentrations by modulating Ca2+-channel activity. CALP2 has also been shown to be a potent activator of alveolar macrophages.

Technical Data

M. Wt 1357.72
Formula C68H104N14O13S
Sequence VKFGVGFKVMVF
Storage Desiccate at -20°C
CAS Number 261969-04-4
PubChem ID 90471211
InChI Key ODWOEJYNFFTQOH-IVGXUUFVSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1357.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.74 mL 3.68 mL 7.37 mL
5 mM 0.15 mL 0.74 mL 1.47 mL
10 mM 0.07 mL 0.37 mL 0.74 mL
50 mM 0.01 mL 0.07 mL 0.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID: 11145661

Ten Broeke et al (2001) Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 15 1831 PMID: 11481245

Ten Broeke et al (2004) Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab.Invest. 84 29 PMID: 14631377

Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676 PMID:


If you know of a relevant reference for CALP2, please let us know.

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2 Citations for CALP2

Citations are publications that use Tocris products. Selected citations for CALP2 include:

Heo et al (2015) Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Sci Rep 5 16895 PMID: 26592929

Fernández-Velasco et al (2011) RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. PLoS One 6 e20863 PMID: 21673970


Do you know of a great paper that uses CALP2 from Tocris? If so please let us know.

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