CALP2

Discontinued Product

CALP2 (Cat. No. 2091) has been withdrawn from sale for commercial reasons.
Cat.No. 2091 - CALP2 | CAS No. 261969-05-5
Description: Cell-permeable calmodulin antagonist
Alternative Names: Calcium-like peptide 2
Datasheet
Citations
Reviews

Biological Activity

Cell-permeable calmodulin (CaM) and troponin C antagonist; binds to the EF-hand/Ca2+-binding site. Inhibits Ca2+/CaM-dependent activation of phosphodiesterase. Increases agonist-induced intracellular [Ca2+] increases and NO production in airway epithelial cells and activates alveolar macrophages. Also inhibits VLA-5-mediated adhesion of mast cells to fibronectin.

Technical Data

M. Wt 881.08
Storage Desiccate at -20°C
CAS Number 261969-05-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

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References

References are publications that support the biological activity of the product.

Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID: 11145661

Ten Broeke et al (2001) Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 15 1831 PMID: 11481245

Ten Broeke et al (2004) Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab.Invest. 84 29 PMID: 14631377

Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676

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