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Cell-permeable calmodulin (CaM) and troponin C antagonist; binds to the EF-hand/Ca2+-binding site. Inhibits Ca2+/CaM-dependent activation of phosphodiesterase. Increases agonist-induced intracellular [Ca2+] increases and NO production in airway epithelial cells and activates alveolar macrophages. Also inhibits VLA-5-mediated adhesion of mast cells to fibronectin.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID: 11145661
Ten Broeke et al (2001) Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 15 1831 PMID: 11481245
Ten Broeke et al (2004) Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab.Invest. 84 29 PMID: 14631377
Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676
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Keywords: CALP2, CALP2 supplier, Cell-permeable, calmodulin, (CaM), and, troponin, C, antagonist;, binds, to, the, EF-hand/Ca2+-binding, site., Inhibits, Ca2+/CaM-dependent, activation, of, phosphodiesterase., Increases, agonist-induced, intracellular, [Ca2+], increases, NO, production, in, airway, epithelial, cel, Calcium-like, peptide, 2, Calcium, Binding, Protein, 2091, Tocris Bioscience
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