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CALP2

Cat. No. 2091 Submit a Review Datasheet / COA / SDS

Discontinued Product

CALP2 (Cat. No. 2091) has been withdrawn from sale for commercial reasons.
Description: Cell-permeable calmodulin antagonist
Alternative Names: Calcium-like peptide 2
Datasheet
Citations
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for CALP2

Cell-permeable calmodulin (CaM) and troponin C antagonist; binds to the EF-hand/Ca2+-binding site. Inhibits Ca2+/CaM-dependent activation of phosphodiesterase. Increases agonist-induced intracellular [Ca2+] increases and NO production in airway epithelial cells and activates alveolar macrophages. Also inhibits VLA-5-mediated adhesion of mast cells to fibronectin.

Technical Data for CALP2

M. Wt 881.08
Storage Desiccate at -20°C
CAS Number 261969-05-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for CALP2

Certificate of Analysis is currently unavailable on-line.
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Safety Datasheet

References for CALP2

References are publications that support the biological activity of the product.

Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID: 11145661

Ten Broeke et al (2001) Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 15 1831 PMID: 11481245

Ten Broeke et al (2004) Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab.Invest. 84 29 PMID: 14631377

Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676

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Keywords: CALP2, CALP2 supplier, Cell-permeable, calmodulin, (CaM), and, troponin, C, antagonist;, binds, to, the, EF-hand/Ca2+-binding, site., Inhibits, Ca2+/CaM-dependent, activation, of, phosphodiesterase., Increases, agonist-induced, intracellular, [Ca2+], increases, NO, production, in, airway, epithelial, cel, Calcium-like, peptide, 2, Calcium, Binding, Protein, 2091, Tocris Bioscience

Citations for CALP2

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