Discontinued Product

Unfortunately CALP2 (Cat. No. 2091) has been withdrawn from sale for commercial reasons.
Cat.No. 2091 - CALP2 | CAS No. 261969-05-5
Description: Cell-permeable calmodulin antagonist
Alternative Names: Calcium-like peptide 2

Biological Activity

Cell-permeable calmodulin (CaM) and troponin C antagonist; binds to the EF-hand/Ca2+-binding site. Inhibits Ca2+/CaM-dependent activation of phosphodiesterase. Increases agonist-induced intracellular [Ca2+] increases and NO production in airway epithelial cells and activates alveolar macrophages. Also inhibits VLA-5-mediated adhesion of mast cells to fibronectin.

Technical Data

M. Wt 881.08
Storage Desiccate at -20°C
CAS Number 261969-05-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 881.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.13 mL 5.67 mL 11.35 mL
5 mM 0.23 mL 1.13 mL 2.27 mL
10 mM 0.11 mL 0.57 mL 1.13 mL
50 mM 0.02 mL 0.11 mL 0.23 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet


References are publications that support the products' biological activity.

Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID: 11145661

Ten Broeke et al (2001) Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 15 1831 PMID: 11481245

Ten Broeke et al (2004) Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab.Invest. 84 29 PMID: 14631377

Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676 PMID:

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