Calhex 231 hydrochloride

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Cat.No. 4387 - Calhex 231 hydrochloride | C25H27ClN2O.HCl | CAS No. 2387505-78-2
Description: Negative allosteric modulator of calcium-sensing receptor (CaSR)
Chemical Name: 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

Negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [3H]inositol phosphate levels elicited by wild-type hCasR activation (IC50= 0.39 μM in transiently transfected HEK293 cells).

Compound Libraries

Calhex 231 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 443.41
Formula C25H27ClN2O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2387505-78-2
PubChem ID 11849513
InChI Key KZPHZSFSFANQIS-GRFVZBLOSA-N
Smiles O=C(C4=CC=C(Cl)C=C4)N[C@@H](CCCC3)[C@H]3N[C@H](C)C1=C2C(C=CC=C2)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 443.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.51 mL 22.55 mL 45.1 mL
2.5 mM 0.9 mL 4.51 mL 9.02 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
25 mM 0.09 mL 0.45 mL 0.9 mL

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2 Citations for Calhex 231 hydrochloride

Citations are publications that use Tocris products. Selected citations for Calhex 231 hydrochloride include:

Yarova et al (2015) Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Diabetologia 7 284ra60 PMID: 25904744

Diakogiannaki et al (2013) Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Oncotarget 56 2688 PMID: 24045836


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Literature in this Area

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