CAF 382

Pricing Availability   Qty
Description: Potent and selective CDKL5 inhibitor
Chemical Name: N-[5-[(5-Propan-2-yl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide trifluoroacetate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for CAF 382

CAF 382 is potent and selective CDKL5 (cyclin-dependent kinase-like 5) inhibitor (IC50 = 10 nM). Exhibits nearly 100-fold selectivity for CDKL5 over CDKL2, low inhibition for CDKL3 and CDKL4 (IC50 = 2.1-2.7 µM), and no inhibition for CDKL1. CAF 382 lacks GSK3β activity. It causes a significant reduction in pSer222 EB2 at 5 nM without a change in total EB2 levels in rat primary cortical neuron cultures. CAF 382 is an analog of SNS 032 (Cat. No. 4075).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-CAF382-1 probe summary on the SGC website.

Technical Data for CAF 382

M. Wt 480.52
Formula C16H22N4O2S2.CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key CZYALDCQIWYWJJ-UHFFFAOYSA-N
Smiles O=C(C1CCNCC1)NC2=NC=C(SCC3=NC=C(C(C)C)O3)S2.O=C(O)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CAF 382

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.05 100
ethanol 9.61 20 with gentle warming

Preparing Stock Solutions for CAF 382

The following data is based on the product molecular weight 480.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.41 mL 20.81 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References for CAF 382

References are publications that support the biological activity of the product.

Castano et al (2023) Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology. Elife 12 e88206 PMID: 37490324


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Citations for CAF 382

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