SNS 032

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Description: Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9
Alternative Names: BMS-387032
Chemical Name: N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for SNS 032

SNS 032 is a cyclin dependent kinase (cdk) inhibitor (reported IC50 values are 0.004 - 0.048, 0.0045 - 0.05, 0.062 - 0.29, 0.2-0.48, 0.4 and 0.45 μM for cdk9, cdk2, cdk7, cdk1, cdk5 and cdk4, respectively). Displays no activity against 190 additional kinases (IC50 >1 μM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

Technical Data for SNS 032

M. Wt 380.53
Formula C17H24N4O2S2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 345627-80-7
PubChem ID 3025986
Smiles CC(C)(C)C1=CN=C(CSC2=CN=C(NC(C3CCNCC3)=O)S2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SNS 032

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.03 50

Preparing Stock Solutions for SNS 032

The following data is based on the product molecular weight 380.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.26 mL 26.28 mL 52.56 mL
2.5 mM 1.05 mL 5.26 mL 10.51 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
25 mM 0.11 mL 0.53 mL 1.05 mL

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Keywords: SNS 032, SNS 032 supplier, SNS032, inhibits, cyclin-depndent, kinase, Cdk, potent, inhibitors, cdk2, cdk7, cdk9, BMS387032, BMS, 387032, BMS-387032, Cyclin-dependent, Kinase, Non-selective, CDKs, 4075, Tocris Bioscience

1 Citation for SNS 032

Citations are publications that use Tocris products. Selected citations for SNS 032 include:

Zhang et al (2015) Regulation and function of phosphorylation on VP8, the major tegument protein of bovine herpesvirus 1. PLoS One 89 4598 PMID: 25673708

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