SNS 032

Pricing Availability Delivery Time Qty
Cat.No. 4075 - SNS 032 | C17H24N4O2S2 | CAS No. 345627-80-7
Description: Potent cdk2, cdk7 and cdk9 inhibitor
Alternative Names: BMS-387032
Chemical Name: N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). Displays no activity against 190 additional kinases (IC50 >1000 nM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

Technical Data

M. Wt 380.53
Formula C17H24N4O2S2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 345627-80-7
PubChem ID 3025986
InChI Key OUSFTKFNBAZUKL-UHFFFAOYSA-N
Smiles CC(C)(C)C1=CN=C(CSC2=CN=C(NC(C3CCNCC3)=O)S2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.03 50

Preparing Stock Solutions

The following data is based on the product molecular weight 380.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.14 mL 26.28 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Misra et al (2004) N-(Cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent J.Med.Chem. 47 1719 PMID: 15027863

Ali et al (2007) SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia 9 370 PMID: 17534442

Conroy et al (2009) SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother.Pharmacol. 64 723 PMID: 19169685

Chen et al (2010) Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line. Cancer Res. 70 6587 PMID: 20663900


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1 Citation for SNS 032

Citations are publications that use Tocris products. Selected citations for SNS 032 include:

Zhang et al (2015) Regulation and function of phosphorylation on VP8, the major tegument protein of bovine herpesvirus 1. PLoS One 89 4598 PMID: 25673708


Do you know of a great paper that uses SNS 032 from Tocris? If so please let us know.

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Literature in this Area

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Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for SNS 032

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