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Cat.No. 6264 - Caerulein | Glp-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2 | CAS No. 17650-98-5
Description: CCK agonist

Biological Activity

CCK agonist. Stimulates biosynthesis of pancreatic enzymes in AR4-2J pancreatic cells in vitro. Induces acute pancreatitis in mice. Also enhances proteasome activity in Gdeg mice.

Technical Data

M. Wt 1352.4
Formula C58H73N13O21S2

(Modifications: X = Glp, Tyr-4 = Tyr(SO3H), Phe-10 = C-terminal amide)

Storage Store at -20°C
CAS Number 17650-98-5
PubChem ID 16132921

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1352.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.74 mL 3.7 mL 7.39 mL
5 mM 0.15 mL 0.74 mL 1.48 mL
10 mM 0.07 mL 0.37 mL 0.74 mL
50 mM 0.01 mL 0.07 mL 0.15 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Murakami et al (2017) Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene 36 1232 PMID: 27546622

Furuyama et al (2016) Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci.Rep. 6 27044 PMID: 27244456

Pradel et al (1993) Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J). Biochem.J. 290 219 PMID: 7679894

If you know of a relevant reference for Caerulein, please let us know.

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Keywords: Caerulein, supplier, Cholecystokinin, Receptors, CCK1, CCK2, agonists, pancreatitis, Non-selective, CCK, Non-selective, CCK, Tocris Bioscience

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