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Biological Activity for Caerulein
Caerulein is a CCK agonist. Stimulates biosynthesis of pancreatic enzymes in AR4-2J pancreatic cells in vitro. Induces acute pancreatitis in mice. Also enhances proteasome activity in Gdeg mice.
Technical Data for Caerulein
(Modifications: X = Glp, Tyr-4 = Tyr(SO3H), Phe-10 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Caerulein
|Solubility||Soluble to 1 mg/ml in water|
References for Caerulein
References are publications that support the biological activity of the product.
Murakami et al (2017) Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene 36 1232 PMID: 27546622
Furuyama et al (2016) Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci.Rep. 6 27044 PMID: 27244456
Pradel et al (1993) Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J). Biochem.J. 290 219 PMID: 7679894
If you know of a relevant reference for Caerulein, please let us know.
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Keywords: Caerulein, Caerulein supplier, Cholecystokinin, Receptors, CCK1, CCK2, agonists, pancreatitis, Non-selective, CCK, 6264, Tocris Bioscience
3 Citations for Caerulein
Citations are publications that use Tocris products. Selected citations for Caerulein include:
Li et al (2021) Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration. Microbiome 9 115 PMID: 34016163
Xiaofeng et al (2022) A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis. Mol Ther 30 1754-1774 PMID: 35077860
Stephen J et al (2020) TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. J Clin Invest 130 2527-2541 PMID: 31999644
Do you know of a great paper that uses Caerulein from Tocris? Please let us know.
Reviews for Caerulein
Average Rating: 5 (Based on 1 Review.)
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Dissolve in recommended solvent and 50microgram/ kg, intraperitoneally administered to mice for 5 times to induce acute pancreatitis.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.