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CCK agonist. Stimulates biosynthesis of pancreatic enzymes in AR4-2J pancreatic cells in vitro. Induces acute pancreatitis in mice. Also enhances proteasome activity in Gdeg mice.
(Modifications: X = Glp, Tyr-4 = Tyr(SO3H), Phe-10 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Murakami et al (2017) Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene 36 1232 PMID: 27546622
Furuyama et al (2016) Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci.Rep. 6 27044 PMID: 27244456
Pradel et al (1993) Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J). Biochem.J. 290 219 PMID: 7679894
If you know of a relevant reference for Caerulein, please let us know.
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Keywords: Caerulein, Caerulein supplier, Cholecystokinin, Receptors, CCK1, CCK2, agonists, pancreatitis, Non-selective, CCK, 6264, Tocris Bioscience
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Dissolve in recommended solvent and 50microgram/ kg, intraperitoneally administered to mice for 5 times to induce acute pancreatitis.
Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.