You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for C16
C16 is a PKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block in vitro. Decreases Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.
Technical Data for C16
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for C16
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for C16
The following data is based on the product molecular weight 268.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||7.45 mL||37.27 mL||74.55 mL|
|2.5 mM||1.49 mL||7.45 mL||14.91 mL|
|5 mM||0.75 mL||3.73 mL||7.45 mL|
|25 mM||0.15 mL||0.75 mL||1.49 mL|
References for C16
References are publications that support the biological activity of the product.
Jammi et al (2003) Small molecule inhibitors of the RNA-dependent protein kinase. Biochem.Biophys.Res.Comm. 308 50 PMID: 12890478
Ingrand et al (2007) The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. FEBS Lett. 581 4473 PMID: 17761171
Couturier et al (2011) Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures. J.Neuroinflammation 8 PMID: 21699726
Tronel et al (2014) The specific PKR inhibitor C16 prevents apoptosis and IL-1 beta production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem.Int. 64 73 PMID: 24211709
If you know of a relevant reference for C16, please let us know.
View Related Products by Product Action
Keywords: C16, C16 supplier, Double-stranded, RNA-dependent, proteins, kinases, PKR, inhibitors, inhibits, neuroprotective, neuroprotection, neuroinflammation, Other, Kinases, 5382, Tocris Bioscience
1 Citation for C16
Citations are publications that use Tocris products. Selected citations for C16 include:
Jiang and Steinle (2019) Epac1 inhibits PKR to reduce NLRP3 inflammasome proteins in retinal endothelial cells. J Inflamm Res 12 153 PMID: 31354329
Do you know of a great paper that uses C16 from Tocris? Please let us know.
Reviews for C16
There are currently no reviews for this product. Be the first to review C16 and earn rewards!
Have you used C16?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.