C14TKL-1

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Cat.No. 1939 - C14TKL-1 | Arg-His-Arg-Thr-Pro-Met-Phe-Tyr-Gly-Leu-Met-NH2
Description: Endogenous NK1 agonist
Alternative Names: Chromosome 14 tachykinin-like peptide 1
Datasheet
Citations
Reviews
Literature

Biological Activity

Endogenous human tachykinin-like peptide and potent agonist for NK1 receptors (EC50 = 1 nM).

Technical Data

M. Wt 1406.7
Formula C63H98N20O13S2
Sequence RHRTPMFYGLM

(Modifications: Met-11 = C-terminal amide)

Storage Desiccate at -20°C
PubChem ID 90488729
InChI Key MMNLXHSWHPGRFE-MRQSSJIPSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Jiang et al (2003) PepPat, a pattern-based oligopeptide homology search method and the identification of a novel tachykinin-like peptide. Mamm.Genome 14 341 PMID: 12856286


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Keywords: C14TKL-1, C14TKL-1 supplier, Endogenous, NK1, agonists, Tachykinin, Receptors, Neurokinin, Chromosome14, tachykinin-like, peptide1, Chromosome, 14, peptide, 1, Receptor, 1939, Tocris Bioscience

Citations for C14TKL-1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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Cardiovascular Poster

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Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.