C 176

Pricing Availability   Qty
Cat.No. 7040 - C 176 | C11H7IN2O4 | CAS No. 314054-00-7
Description: mSTING antagonist
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

mSTING antagonist. Covalently binds Cys91 of mouse but not human STING. Blocks activation-induced palmitoylation of STING and formation of STING clusters. Reduces CMA (Cat. No. 6677) -induced increase in serum IFNs in vivo and suppresses systemic inflammation in a mouse inflammatory disease model.

Technical Data

M. Wt 358.09
Formula C11H7IN2O4
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 314054-00-7
PubChem ID 1103958
InChI Key JBIKQXOZLBLMKI-UHFFFAOYSA-N
Smiles IC1=CC=C(C=C1)NC(C2=CC=C([N+]([O-])=O)O2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 358.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.96 mL 27.93 mL
5 mM 0.56 mL 2.79 mL 5.59 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Haag et al (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559 269 PMID: 29973723


If you know of a relevant reference for C 176, please let us know.

View Related Products by Target

View Related Products by Product Action

View all STING-Dependent Signaling Antagonists

Keywords: C 176, C 176 supplier, C176, mSTING, murine, mouse, stimulator, of, interferon, genes, antagonists, antagonism, covalent, covalently, STING-Dependent, Signaling, 7040, Tocris Bioscience

Citations for C 176

Citations are publications that use Tocris products.

Currently there are no citations for C 176. Do you know of a great paper that uses C 176 from Tocris? Please let us know.

Reviews for C 176

There are currently no reviews for this product. Be the first to review C 176 and earn rewards!

Have you used C 176?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation