BVD 10

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Cat.No. 2177 - BVD 10 | Ile-Asn-Pro-Ile-Tyr-Arg-Leu-Arg-Tyr-OMe | CAS No. 262418-00-8
Description: Highly selective NPY Y1 receptor antagonist; devoid of Y4 agonist activity
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Highly selective NPY Y1 receptor antagonist. Ki values are 25.7, 1420, 2403 and 7100 nM at Y1, Y2, Y4 and Y5 receptors respectively. Devoid of agonist activity at Y4 receptors.

Licensing Information

Sold under license

Technical Data

M. Wt 1221.46
Formula C58H92N16O13
Sequence INPIYRLRY

(Modifications: Tyr-9 = Tyr-OMe)

Storage Desiccate at -20°C
CAS Number 262418-00-8
PubChem ID 10820196
InChI Key JLQHEFJKMUJISI-QUCBMPEKSA-N
Smiles [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1221.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.82 mL 4.09 mL 8.19 mL
5 mM 0.16 mL 0.82 mL 1.64 mL
10 mM 0.08 mL 0.41 mL 0.82 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Balasubramaniam et al (2001) Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro30, Tyr32, Leu34]NPY(28-36)-NH2 (BW1911U90). J.Med.Chem. 44 1479 PMID: 11334558

Jois and Balasubramaniam (2003) Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity. Peptides 24 1035 PMID: 14499282

Jois et al (2006) Modeling of neuropeptide receptors Y1, Y4, Y5, and docking studies with neuropeptide antagonist. J.Biomol.Struct.Dyn. 23 497 PMID: 16494499


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1 Citation for BVD 10

Citations are publications that use Tocris products. Selected citations for BVD 10 include:

Demorrow et al (2011) Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion. Physiol Rep 300 C1078 PMID: 21270292


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