BU 226 hydrochloride

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Cat.No. 1091 - BU 226 hydrochloride | C12H11N3.HCl | CAS No. 1186195-56-1
Description: Potent, highly selective I2 ligand
Chemical Name: 2-(4,5-Dihydroimidazol-2-yl)isoquinoline hydrochloride
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

A high affinity ligand for I2 imidazoline sites (Ki = 2.7 nM) with very high selectivity (> 2000-fold) over α2-adrenoceptors (Ki = 6700 nM).

Technical Data

M. Wt 233.7
Formula C12H11N3.HCl
Storage Store at RT
CAS Number 1186195-56-1
PubChem ID 56972194
InChI Key NIGHNKWLMSRCOZ-UHFFFAOYSA-N
Smiles Cl.C1CN=C(N1)C1=CC2=CC=CC=C2C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 233.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.28 mL 21.39 mL 42.79 mL
5 mM 0.86 mL 4.28 mL 8.56 mL
10 mM 0.43 mL 2.14 mL 4.28 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hudson et al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81 PMID: 10415900

Lione et al (1997) BU226: A selective ligand for rat brain imidazoline I2 sites. Soc.Neurosci.Abstr. 23 695.28


If you know of a relevant reference for BU 226 hydrochloride, please let us know.

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1 Citation for BU 226 hydrochloride

Citations are publications that use Tocris products. Selected citations for BU 226 hydrochloride include:

Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423


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Literature in this Area

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