BU 226 hydrochloride

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Cat.No. 1091 - BU 226 hydrochloride | C12H11N3.HCl | CAS No. 1186195-56-1
Description: Potent, highly selective I2 ligand
Chemical Name: 2-(4,5-Dihydroimidazol-2-yl)isoquinoline hydrochloride
Citations (1)

Biological Activity

A high affinity ligand for I2 imidazoline sites (Ki = 2.7 nM) with very high selectivity (> 2000-fold) over α2-adrenoceptors (Ki = 6700 nM).

Technical Data

M. Wt 233.7
Formula C12H11N3.HCl
Storage Store at RT
CAS Number 1186195-56-1
PubChem ID 56972194
Smiles Cl.C1CN=C(N1)C1=CC2=CC=CC=C2C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 233.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.28 mL 21.39 mL 42.79 mL
5 mM 0.86 mL 4.28 mL 8.56 mL
10 mM 0.43 mL 2.14 mL 4.28 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Hudson et al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81 PMID: 10415900

Lione et al (1997) BU226: A selective ligand for rat brain imidazoline I2 sites. Soc.Neurosci.Abstr. 23 695.28 PMID:

If you know of a relevant reference for BU 226 hydrochloride, please let us know.

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1 Citation for BU 226 hydrochloride

Citations are publications that use Tocris products. Selected citations for BU 226 hydrochloride include:

GrĂ¼ndemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423

Do you know of a great paper that uses BU 226 hydrochloride from Tocris? If so please let us know.

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