BU 224 hydrochloride

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Cat.No. 0725 - BU 224 hydrochloride | C12H11N3.HCl | CAS No. 205437-64-5
Description: Potent, selective I2 ligand. Putative antagonist
Chemical Name: 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

High affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

Technical Data

M. Wt 233.7
Formula C12H11N3.HCl
Storage Desiccate at RT
CAS Number 205437-64-5
PubChem ID 11957470
InChI Key DDFHQXAQWZWRSQ-UHFFFAOYSA-N
Smiles Cl.C1CN=C(N1)C1=NC2=CC=CC=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.34 10

Preparing Stock Solutions

The following data is based on the product molecular weight 233.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 42.79 mL 213.95 mL 427.9 mL
0.5 mM 8.56 mL 42.79 mL 85.58 mL
1 mM 4.28 mL 21.39 mL 42.79 mL
5 mM 0.86 mL 4.28 mL 8.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hudson et al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81 PMID: 10415900

MacInnes and Dut (2004) Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952 PMID: 15545290

Sanchez-Blasquez et al (2000) Activation of I2-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146 PMID: 10781010

Hudson et al (1994) Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I2) sites). Br.J.Pharmacol. 112 320P


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2 Citations for BU 224 hydrochloride

Citations are publications that use Tocris products. Selected citations for BU 224 hydrochloride include:

Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423

Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010


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Literature in this Area

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