You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
BU 224 hydrochloride
High affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 233.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||42.79 mL||213.95 mL||427.9 mL|
|0.5 mM||8.56 mL||42.79 mL||85.58 mL|
|1 mM||4.28 mL||21.39 mL||42.79 mL|
|5 mM||0.86 mL||4.28 mL||8.56 mL|
References are publications that support the biological activity of the product.
Hudson et al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81 PMID: 10415900
MacInnes and Dut (2004) Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952 PMID: 15545290
Sanchez-Blasquez et al (2000) Activation of I2-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146 PMID: 10781010
Hudson et al (1994) Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I2) sites). Br.J.Pharmacol. 112 320P
If you know of a relevant reference for BU 224 hydrochloride, please let us know.
Keywords: BU 224 hydrochloride, BU 224 hydrochloride supplier, Potent, selective, I2, ligand, Putative, antagonists, Imidazoline, Receptors, BU224, hydrochloride, 0725, Tocris Bioscience
2 Citations for BU 224 hydrochloride
Citations are publications that use Tocris products. Selected citations for BU 224 hydrochloride include:
Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423
Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010
Do you know of a great paper that uses BU 224 hydrochloride from Tocris? Please let us know.
Reviews for BU 224 hydrochloride
There are currently no reviews for this product. Be the first to review BU 224 hydrochloride and earn rewards!
Have you used BU 224 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells