BTC

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Cat.No. 5421 - BTC | C14H10O2S | CAS No. 63676-22-2
Description: Selective estrogen receptor modulator (SERM)
Chemical Name: 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
Purity: ≥99% (HPLC)
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Biological Activity

Selective estrogen receptor modulator (SERM); induces regression of tamoxifen-resistant, hormone independent xenograft tumors. Displays no significant gain in uterine weight in treated mice.

Technical Data

M. Wt 242.29
Formula C14H10O2S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 63676-22-2
PubChem ID 445920
InChI Key MDGWZLQPNOETLH-UHFFFAOYSA-N
Smiles OC(C=C3)=CC=C3C2=CC1=CC=C(O)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.11 50
ethanol 12.11 50

Preparing Stock Solutions

The following data is based on the product molecular weight 242.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.13 mL 20.64 mL 41.27 mL
5 mM 0.83 mL 4.13 mL 8.25 mL
10 mM 0.41 mL 2.06 mL 4.13 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Molloy et al (2014) Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol.Cancer.Ther. 13 2515 PMID: 25205655


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View all Estrogen and Related Receptor Modulators

Keywords: oestrogen receptors modulators SERM tamoxifen resistant antitumor antitumour Estrogen and Related Receptors

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for BTC

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.

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