BTC

Pricing Availability Delivery Time Qty
Cat.No. 5421 - BTC | C14H10O2S | CAS No. 63676-22-2
Description: Selective estrogen receptor modulator (SERM)
Chemical Name: 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Selective estrogen receptor modulator (SERM); induces regression of tamoxifen-resistant, hormone independent xenograft tumors. Displays no significant gain in uterine weight in treated mice.

Technical Data

M. Wt 242.29
Formula C14H10O2S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 63676-22-2
PubChem ID 445920
InChI Key MDGWZLQPNOETLH-UHFFFAOYSA-N
Smiles OC(C=C3)=CC=C3C2=CC1=CC=C(O)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.11 50
ethanol 12.11 50

Preparing Stock Solutions

The following data is based on the product molecular weight 242.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.13 mL 20.64 mL 41.27 mL
5 mM 0.83 mL 4.13 mL 8.25 mL
10 mM 0.41 mL 2.06 mL 4.13 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Molloy et al (2014) Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol.Cancer.Ther. 13 2515 PMID: 25205655


If you know of a relevant reference for BTC, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Estrogen and Related Receptor Modulators

Keywords: BTC, supplier, oestrogen, receptors, modulators, SERM, tamoxifen, resistant, antitumor, antitumour, Estrogen, and, Related, Receptors, Estrogen, and, Related, Receptors, Tocris Bioscience

Citations for BTC

Citations are publications that use Tocris products.

Currently there are no citations for BTC. Do you know of a great paper that uses BTC from Tocris? If so please let us know.

Reviews for BTC

There are currently no reviews for this product. Be the first to review BTC and earn rewards!

Have you used BTC?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for BTC

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.