BTC

Discontinued Product

BTC (Cat. No. 5421) has been withdrawn from sale for commercial reasons.
Cat.No. 5421 - BTC | C14H10O2S | CAS No. 63676-22-2
Description: Selective estrogen receptor modulator (SERM)
Chemical Name: 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)

Biological Activity

Selective estrogen receptor modulator (SERM); induces regression of tamoxifen-resistant, hormone independent xenograft tumors. Displays no significant gain in uterine weight in treated mice.

Technical Data

M. Wt 242.29
Formula C14H10O2S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 63676-22-2
PubChem ID 445920
InChI Key MDGWZLQPNOETLH-UHFFFAOYSA-N
Smiles OC(C=C3)=CC=C3C2=CC1=CC=C(O)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Molloy et al (2014) Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol.Cancer.Ther. 13 2515 PMID: 25205655

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Citations for BTC

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for BTC

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.