Selective estrogen receptor modulator (SERM); induces regression of tamoxifen-resistant, hormone independent xenograft tumors. Displays no significant gain in uterine weight in treated mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 242.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.25 mL||41.27 mL||82.55 mL|
|2.5 mM||1.65 mL||8.25 mL||16.51 mL|
|5 mM||0.83 mL||4.13 mL||8.25 mL|
|25 mM||0.17 mL||0.83 mL||1.65 mL|
References are publications that support the biological activity of the product.
Molloy et al (2014) Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol.Cancer.Ther. 13 2515 PMID: 25205655
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Keywords: BTC, BTC supplier, oestrogen, receptors, modulators, SERM, tamoxifen, resistant, antitumor, antitumour, Estrogen, and, Related, Receptors, 5421, Tocris Bioscience
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