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Cat.No. 5421 - BTC | C14H10O2S | CAS No. 63676-22-2
Description: Selective estrogen receptor modulator (SERM)
Chemical Name: 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
Purity: ≥99% (HPLC)

Biological Activity

Selective estrogen receptor modulator (SERM); induces regression of tamoxifen-resistant, hormone independent xenograft tumors. Displays no significant gain in uterine weight in treated mice.

Technical Data

M. Wt 242.29
Formula C14H10O2S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 63676-22-2
PubChem ID 445920
Smiles OC(C=C3)=CC=C3C2=CC1=CC=C(O)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 12.11 50
ethanol 12.11 50

Preparing Stock Solutions

The following data is based on the product molecular weight 242.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.25 mL 41.27 mL 82.55 mL
2.5 mM 1.65 mL 8.25 mL 16.51 mL
5 mM 0.83 mL 4.13 mL 8.25 mL
25 mM 0.17 mL 0.83 mL 1.65 mL

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References are publications that support the biological activity of the product.

Molloy et al (2014) Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol.Cancer.Ther. 13 2515 PMID: 25205655

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Nuclear Receptors

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Pathways for BTC


Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.