BSJ-04-132

Pricing Availability   Qty
Cat.No. 6937 - BSJ-04-132 | C42H49N11O7
Description: Selective Cdk4 degrader
Chemical Name: 7-Cyclopentyl-2-[[5-[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]oxy]acetamido]butyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethyl-7H-pyrrolo[2,3d]pyrimidine-6-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data

M. Wt 819.92
Formula C42H49N11O7
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key GWLSXEHHNOBFOI-UHFFFAOYSA-N
Smiles O=C(COC1=C2C(C(N(C3C(NC(CC3)=O)=O)C2=O)=O)=CC=C1)NCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC7=C(C=C(C(N(C)C)=O)N7C8CCCC8)C=N6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 81.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 819.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.22 mL 6.1 mL 12.2 mL
5 mM 0.24 mL 1.22 mL 2.44 mL
10 mM 0.12 mL 0.61 mL 1.22 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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References

References are publications that support the biological activity of the product.

Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID: 30802347


If you know of a relevant reference for BSJ-04-132, please let us know.

Keywords: BSJ-04-132, BSJ-04-132 supplier, cyclin, dependent, kinase, cdk4, degraders, degrades, selective, protac, proteolysis, targeting, chimera, Active, Degraders, Cyclin-dependent, Kinase, 6937, Tocris Bioscience

Citations for BSJ-04-132

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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