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Submit ReviewBSJ-04-132
Discontinued Product
6937 has been discontinued.
View all Cyclin Dependent Kinase (CDK) Degraders products.
Description: Selective Cdk4 Degrader (PROTAC®)
Chemical Name: 7-Cyclopentyl-2-[[5-[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]oxy]acetamido]butyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethyl-7H-pyrrolo[2,3d]pyrimidine-6-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for BSJ-04-132
BSJ-04-132 is a selective Cdk4 Degrader (PROTAC®). Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Dana-Farber Cancer Institute
Technical Data for BSJ-04-132
| M. Wt | 819.92 |
| Formula | C42H49N11O7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2349356-39-2 |
| InChI Key | GWLSXEHHNOBFOI-UHFFFAOYSA-N |
| Smiles | O=C(COC1=C2C(C(N(C3C(NC(CC3)=O)=O)C2=O)=O)=CC=C1)NCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC7=C(C=C(C(N(C)C)=O)N7C8CCCC8)C=N6 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BSJ-04-132
References for BSJ-04-132
References are publications that support the biological activity of the product.
Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID: 30802347
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Keywords: BSJ-04-132, BSJ-04-132 supplier, cyclin, dependent, kinase, cdk4, active, degraders, degrades, selective, protac, PROTACs, proteolysis, targeting, chimera, Active, Degraders, Cyclin-dependent, Kinase, CDK4, Subfamily, Cyclin, Dependent, (CDK), 6937, Tocris Bioscience
Citations for BSJ-04-132
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Currently there are no citations for BSJ-04-132.
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TPD and Induced Proximity Research Product Guide
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia