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Biological Activity for BSJ-04-132
BSJ-04-132 is a selective Cdk4 Degrader (PROTAC®). Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Sold under license from Dana-Farber Cancer Institute
Technical Data for BSJ-04-132
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BSJ-04-132
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BSJ-04-132
The following data is based on the product molecular weight 819.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.22 mL||6.1 mL||12.2 mL|
|5 mM||0.24 mL||1.22 mL||2.44 mL|
|10 mM||0.12 mL||0.61 mL||1.22 mL|
|50 mM||0.02 mL||0.12 mL||0.24 mL|
References for BSJ-04-132
References are publications that support the biological activity of the product.
Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID: 30802347
If you know of a relevant reference for BSJ-04-132, please let us know.
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Keywords: BSJ-04-132, BSJ-04-132 supplier, cyclin, dependent, kinase, cdk4, active, degraders, degrades, selective, protac, PROTACs, proteolysis, targeting, chimera, Active, Degraders, Cyclin-dependent, Kinase, CDK4, Subfamily, 6937, Tocris Bioscience
Citations for BSJ-04-132
Citations are publications that use Tocris products.
Currently there are no citations for BSJ-04-132. Do you know of a great paper that uses BSJ-04-132 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia