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Cat.No. 6938 - BSJ-03-204 | C43H48N10O8 | CAS No. 2349356-09-6
Description: Selective Cdk4/6 degrader
Chemical Name: N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity

Selective Cdk4/6 degrader. Displays cereblon-dependent degradation with no effect on IKZF1/3 in Molt4 cells. Induces degradation of Cdk4/6 and G1 cell cycle arrest, and inhibits cell proliferation in a mantle cell lymphoma (MCL) cell line.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data

M. Wt 832.92
Formula C43H48N10O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2349356-09-6
Smiles CC1=C(C(N(C2=C1C=NC(NC3=CC=C(C=N3)N4CCN(CC4)CCCCNC(COC5=C6C(C(N(C6=O)C7C(NC(CC7)=O)=O)=O)=CC=C5)=O)=N2)C8CCCC8)=O)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.66 20

Preparing Stock Solutions

The following data is based on the product molecular weight 832.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6 mL 30.01 mL 60.03 mL
1 mM 1.2 mL 6 mL 12.01 mL
2 mM 0.6 mL 3 mL 6 mL
10 mM 0.12 mL 0.6 mL 1.2 mL

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References are publications that support the biological activity of the product.

Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID: 30802347

If you know of a relevant reference for BSJ-03-204, please let us know.

Keywords: BSJ-03-204, BSJ-03-204 supplier, protacs, degraders, selective, cdk4, cdk6, cyclin, dependent, kinase, degrades, proteolysis, targeting, chimera, active, Active, Degraders, Cyclin-dependent, Kinase, 6938, Tocris Bioscience

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Literature in this Area

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