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Biological Activity for BSJ-03-204
BSJ-03-204 is a selective Cdk4/6 Degrader (PROTAC®). Displays cereblon-dependent degradation with no effect on IKZF1/3 in Molt4 cells. Induces degradation of Cdk4/6 and G1 cell cycle arrest, and inhibits cell proliferation in a mantle cell lymphoma (MCL) cell line.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Sold under license from Dana-Farber Cancer Institute
Technical Data for BSJ-03-204
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BSJ-03-204
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BSJ-03-204
The following data is based on the product molecular weight 832.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||6 mL||30.01 mL||60.03 mL|
|1 mM||1.2 mL||6 mL||12.01 mL|
|2 mM||0.6 mL||3 mL||6 mL|
|10 mM||0.12 mL||0.6 mL||1.2 mL|
References for BSJ-03-204
References are publications that support the biological activity of the product.
Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID: 30802347
If you know of a relevant reference for BSJ-03-204, please let us know.
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Keywords: BSJ-03-204, BSJ-03-204 supplier, protacs, active, degraders, selective, cdk4, cdk6, cyclin, dependent, kinase, degrades, proteolysis, targeting, chimera, PROTAC, Active, Degraders, CDK4, Subfamily, 6938, Tocris Bioscience
Citations for BSJ-03-204
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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