Bryostatin 3

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Cat.No. 5238 - Bryostatin 3 | C46H64O17 | CAS No. 143370-84-7
Description: Potent protein kinase C activator
Chemical Name: (4S,5S,7E,9R,11Z,13S,15S,17S,19R,21R,25R,27R,27aS)-17-(Acetyloxy)-4,5,6,9,10,11,12,13,14,15,16,17,18,19, 20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-[(1R)-1-hydroxyethyl]-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:9,13:15,19-triepoxy-2H-furo[2,3-e]oxacyclohexacosin-4-yl-(2E,4E)-2,4-octadienoic acid ester
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent protein kinase C activator (KI = 2.75 nM). Attenuates phorbol 12-myristate 13-acetate (Cat. No. 1201) inhibition of GH4C1 pituitary cell proliferation in vitro.

Technical Data

M. Wt 888.99
Formula C46H64O17
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 143370-84-7
PubChem ID 10395929
InChI Key BSNHYLUEHJOXFN-HBUIWOJHSA-N
Smiles O=C(O[C@@H]([C@@H](C)O)C[C@@H](O5)[C@H]3O4)C[C@H](O)C[C@H](C[C@H](OC(C)=O)C(C)2C)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]5(O)[C@@H](OC(/C=C/C=C/CCC)=O)C3=CC4=O)C/C1=C\C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 888.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.12 mL 5.62 mL 11.25 mL
5 mM 0.22 mL 1.12 mL 2.25 mL
10 mM 0.11 mL 0.56 mL 1.12 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mackanos et al (1991) Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. J.Biol.Chem. 266 1120 PMID: 1904062

Wender et al (1988) Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc.Natl.Acad.Sci.U.S.A. 85 7197 PMID: 3174627


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