Bryostatin 3

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Cat.No. 5238 - Bryostatin 3 | C46H64O17 | CAS No. 143370-84-7
Description: Potent protein kinase C activator
Chemical Name: (4S,5S,7E,9R,11Z,13S,15S,17S,19R,21R,25R,27R,27aS)-17-(Acetyloxy)-4,5,6,9,10,11,12,13,14,15,16,17,18,19, 20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-[(1R)-1-hydroxyethyl]-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:9,13:15,19-triepoxy-2H-furo[2,3-e]oxacyclohexacosin-4-yl-(2E,4E)-2,4-octadienoic acid ester
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent protein kinase C activator (KI = 2.75 nM). Attenuates phorbol 12-myristate 13-acetate (Cat. No. 1201) inhibition of GH4C1 pituitary cell proliferation in vitro.

Technical Data

M. Wt 888.99
Formula C46H64O17
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 143370-84-7
PubChem ID 10395929
InChI Key BSNHYLUEHJOXFN-HBUIWOJHSA-N
Smiles O=C(O[C@@H]([C@@H](C)O)C[C@@H](O5)[C@H]3O4)C[C@H](O)C[C@H](C[C@H](OC(C)=O)C(C)2C)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]5(O)[C@@H](OC(/C=C/C=C/CCC)=O)C3=CC4=O)C/C1=C\C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble in ethanol

References

References are publications that support the biological activity of the product.

Mackanos et al (1991) Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. J.Biol.Chem. 266 1120 PMID: 1904062

Wender et al (1988) Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc.Natl.Acad.Sci.U.S.A. 85 7197 PMID: 3174627


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