BRD 9757

Pricing Availability   Qty
Description: Potent and selective HDAC6 inhibitor
Chemical Name: N-Hydroxy-1-cyclopentene-1-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity for BRD 9757

BRD 9757 is a potent and selective HDAC6 inhibitor (IC50 = 30 nM). Displays selectivity for HDAC6 over Class I HDACS (>20-fold) and Class II HDACs (>400-fold).

Technical Data for BRD 9757

M. Wt 127.14
Formula C6H9NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1423058-85-8
PubChem ID 71655802
InChI Key RYYGSXXWQSXKRP-UHFFFAOYSA-N
Smiles ONC(C1=CCCC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BRD 9757

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.36 50
DMSO 12.71 100

Preparing Stock Solutions for BRD 9757

The following data is based on the product molecular weight 127.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.87 mL 39.33 mL 78.65 mL
5 mM 1.57 mL 7.87 mL 15.73 mL
10 mM 0.79 mL 3.93 mL 7.87 mL
50 mM 0.16 mL 0.79 mL 1.57 mL

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References for BRD 9757

References are publications that support the biological activity of the product.

Wagner et al (2013) Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J.Med.Chem. 56 1772 PMID: 23368884


If you know of a relevant reference for BRD 9757, please let us know.

View Related Products by Product Action

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Citations for BRD 9757

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Literature in this Area

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