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Submit ReviewBRD 9757
Description: Potent and selective HDAC6 inhibitor
Chemical Name: N-Hydroxy-1-cyclopentene-1-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for BRD 9757
BRD 9757 is a potent and selective HDAC6 inhibitor (IC50 = 30 nM). Displays selectivity for HDAC6 over Class I HDACS (>20-fold) and Class II HDACs (>400-fold).
Technical Data for BRD 9757
| M. Wt | 127.14 |
| Formula | C6H9NO2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1423058-85-8 |
| PubChem ID | 71655802 |
| InChI Key | RYYGSXXWQSXKRP-UHFFFAOYSA-N |
| Smiles | ONC(C1=CCCC1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BRD 9757
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 6.36 | 50 | |
| DMSO | 12.71 | 100 |
Preparing Stock Solutions for BRD 9757
The following data is based on the product molecular weight 127.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.87 mL | 39.33 mL | 78.65 mL |
| 5 mM | 1.57 mL | 7.87 mL | 15.73 mL |
| 10 mM | 0.79 mL | 3.93 mL | 7.87 mL |
| 50 mM | 0.16 mL | 0.79 mL | 1.57 mL |
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Product Datasheets for BRD 9757
References for BRD 9757
References are publications that support the biological activity of the product.
Wagner et al (2013) Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J.Med.Chem. 56 1772 PMID: 23368884
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Citations for BRD 9757
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