BRD 4770

Pricing Availability Delivery Time Qty
Cat.No. 6282 - BRD 4770 | C25H23N3O3 | CAS No. 1374601-40-7
Description: G9a inhibitor and S-adenosyl methionine mimetic; cell permeable
Chemical Name: Methyl-2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

G9a inhibitor and S-adenosyl methionine (SAM) mimetic. Inhibits methylation of H3K9 (EC50 ~ 5 μM) and induces senescence in PANC-1 cells. Induces ATM activation without DNA damage. Cell permeable.

Technical Data

M. Wt 413.47
Formula C25H23N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1374601-40-7
PubChem ID 72193870
InChI Key UCGWYCMPZXDHNR-UHFFFAOYSA-N
Smiles COC(C1=CC=C2N(C(NC(C3=CC=CC=C3)=O)=NC2=C1)CCCC4=CC=CC=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.27 20

Preparing Stock Solutions

The following data is based on the product molecular weight 413.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.09 mL 24.19 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Yuan et al (2012) A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem.Biol. 7 1152 PMID: 22536950


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Citations for BRD 4770

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Literature in this Area

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Cancer

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Epigenetics Scientific Review

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