BPTES

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Cat.No. 5301 - BPTES | C24H24N6O2S3 | CAS No. 314045-39-1
Description: Selective allosteric glutaminase (GLS1) inhibitor
Chemical Name: N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Allosteric glutaminase (GLS1) inhibitor (IC50 = 3.3 μM). Selective for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.

Technical Data

M. Wt 524.68
Formula C24H24N6O2S3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 314045-39-1
PubChem ID 3372016
InChI Key MDJIPXYRSZHCFS-UHFFFAOYSA-N
Smiles O=C(NC2=NN=C(CCSCCC4=NN=C(S4)NC(CC3=CC=CC=C3)=O)S2)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.49 20

Preparing Stock Solutions

The following data is based on the product molecular weight 524.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.53 mL 19.06 mL
5 mM 0.38 mL 1.91 mL 3.81 mL
10 mM 0.19 mL 0.95 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Le et al (2012) Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell.Metab. 15 110 PMID: 22225880

Shukla et al (2012) Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J.Med.Chem. 55 10551 PMID: 23151085

DeLaBarre et al (2011) Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 50 10764 PMID: 22049910


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Keywords: BPTES, supplier, allosteric, glutaminases, gls1, inhibitors, inhibits, selective, Glutaminase, Glutaminase, Tocris Bioscience

Citations for BPTES

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cancer Metabolism

Cancer Metabolism Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.

Pathways for BPTES

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