Bombinakinin M

Pricing Availability Delivery Time Qty
Cat.No. 2371 - Bombinakinin M | Asp-Leu-Pro-Lys-Ile-Asn-Arg-Lys-Gly-ProArg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | CAS No. 509151-65-9
Description: Potent bradykinin receptor agonist
Alternative Names: Maximakinin
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent bradykinin receptor agonist. Highly selective for mammalian arterial smooth muscle bradykinin receptors, displaying ~ 50-fold greater potency than bradykinin. Elicits dose-dependent contractile effects in smooth muscle of guinea pig ileum (EC50 = 4.0 nM).

Technical Data

M. Wt 2179.55
Formula C100H159N31O24
Sequence DLPKINRKGPRPPGFSPFR
Storage Desiccate at -20°C
CAS Number 509151-65-9
PubChem ID 90473828
InChI Key ZEEWOWMYALYVCG-UOGIEMGNSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2179.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.46 mL 2.29 mL 4.59 mL
5 mM 0.09 mL 0.46 mL 0.92 mL
10 mM 0.05 mL 0.23 mL 0.46 mL
50 mM 0.01 mL 0.05 mL 0.09 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Lai et al (2001) A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identicals copies of the final product. Biochem.Biophys.Res.Comm. 286 259

O'Rourke et al (2004) The smooth muscle pharmacology of maximakinin, a receptor-selective, bradykinin-related nonadecapeptide from the venom of the Chinese toad, Bombina maxima. Regul.Peptides 121 65

Lee et al (2005) Cloning of bradykinin precursor cDNAs from skin of Bombina maxima reveals novel bombinakinin M antagonists and a bradykinin potential peptide. Regul.Peptides 127 207


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