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Description: Ten-eleven translocation methylcytosine dioxygenase (TET) inhibitor
Chemical Name: 4-Amino-1-[1,1'-biphenyl]-3-yl-5-chloro-2(1H)-pyrimidinone
Purity: ≥98% (HPLC)

Biological Activity for Bobcat339

Bobcat339 is a selective cytosine-based inhibitor of ten-eleven translocation methylcytosine dioxygenase (TET) (IC50 values are 33 and 73 μM for TET1 and TET2, respectively). Bobcat339 reduces DNA 5-hydroxymethylcytosine (5hmC) levels in cells without inhibiting the DNA methyltransferase DNMT3a.

Technical Data for Bobcat339

M. Wt 297.74
Formula C16H12ClN3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2280037-51-4
PubChem ID 138319673
Smiles NC1=NC(N(C2=CC(C3=CC=CC=C3)=CC=C2)C=C1Cl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bobcat339

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.77 100
ethanol 1.49 5

Preparing Stock Solutions for Bobcat339

The following data is based on the product molecular weight 297.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.79 mL 33.59 mL
5 mM 0.67 mL 3.36 mL 6.72 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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References for Bobcat339

References are publications that support the biological activity of the product.

Chua et al (2019) Cytosine-based TET enzyme inhibitors. ACS Med.Chem.Lett. 10 180 PMID: 30783500

Blecua et al (2020) The DNA methylation landscape of hematological malignancies: an update. Mol.Oncol. 14 1616 PMID: 32526054

If you know of a relevant reference for Bobcat339, please let us know.

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Citations for Bobcat339

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