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Biological Activity for Bobcat339
Bobcat339 is a selective cytosine-based inhibitor of ten-eleven translocation methylcytosine dioxygenase (TET) (IC50 values are 33 and 73 μM for TET1 and TET2, respectively). Bobcat339 reduces DNA 5-hydroxymethylcytosine (5hmC) levels in cells without inhibiting the DNA methyltransferase DNMT3a.
Technical Data for Bobcat339
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Bobcat339
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Bobcat339
The following data is based on the product molecular weight 297.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.36 mL||16.79 mL||33.59 mL|
|5 mM||0.67 mL||3.36 mL||6.72 mL|
|10 mM||0.34 mL||1.68 mL||3.36 mL|
|50 mM||0.07 mL||0.34 mL||0.67 mL|
References for Bobcat339
References are publications that support the biological activity of the product.
Chua et al (2019) Cytosine-based TET enzyme inhibitors. ACS Med.Chem.Lett. 10 180 PMID: 30783500
Blecua et al (2020) The DNA methylation landscape of hematological malignancies: an update. Mol.Oncol. 14 1616 PMID: 32526054
If you know of a relevant reference for Bobcat339, please let us know.
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Keywords: Bobcat339, Bobcat339 supplier, Bobcat339, inhibitors, inhibits, hematopoietic, hematopoiesis, haematopoietic, malignancies, leukemia, lymphoma, methylation, ten-eleven, translocation, methylcytosine, dioxygenase, TET, Other, Oxygenases/Oxidases, 6977, Tocris Bioscience
Citations for Bobcat339
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