BMY 14802 hydrochloride

Discontinued Product

BMY 14802 hydrochloride (Cat. No. 1440) has been withdrawn from sale for commercial reasons.
Description: Sigma antagonist. Antipsychotic agent
Chemical Name: α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol hydrochloride
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for BMY 14802 hydrochloride

BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC50 = 112 nM) with modest to weak affinity for 5-HT1A and α1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.

Licensing Information

Sold with the permission of Bristol-Myers Squibb Company

Technical Data for BMY 14802 hydrochloride

M. Wt 384.86
Formula C18H22F2N4O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 105565-55-7
PubChem ID 3086514
Smiles Cl.OC(CCCN1CCN(CC1)C1=NC=C(F)C=N1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BMY 14802 hydrochloride

References for BMY 14802 hydrochloride

References are publications that support the biological activity of the product.

Taylor et al (1993) A role for sigma binding in the antipsychotic profile of BMY 14802? NIDA Res.Monogr. 133 125 PMID: 8232511

Yevich et al (1992) Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J.Med.Chem. 35 4516 PMID: 1361578

Zhang et al (1993) Further characterization of the effects of BMY 14802 on DA neuronal activity. Synapse 15 276 PMID: 7908761

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Keywords: BMY 14802 hydrochloride, BMY 14802 hydrochloride supplier, σ, sigma, antagonists, Antipsychotic, agent, General, Receptors, BMY14802, Sigma-Related, 1440, Tocris Bioscience

2 Citations for BMY 14802 hydrochloride

Citations are publications that use Tocris products. Selected citations for BMY 14802 hydrochloride include:

Bhide et al (2013) The effects of BMY-14802 against L-DOPA- and DA agonist-induced dyskinesia in the hemiparkinsonian rat. Psychopharmacology (Berl) 227 533 PMID: 23389756

Paquette et al (2008) σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias. Reprod Biol Endocrinol 19 111 PMID: 18281903

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