BMY 14802 hydrochloride

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Cat.No. 1440 - BMY 14802 hydrochloride | C18H22F2N4O.HCl | CAS No. 105565-55-7
Description: Sigma antagonist. Antipsychotic agent
Chemical Name: α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent sigma receptor antagonist (IC50 = 112 nM) with modest to weak affinity for 5-HT1A and α1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.

Licensing Information

Sold with the permission of Bristol-Myers Squibb Company

Technical Data

M. Wt 384.86
Formula C18H22F2N4O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 105565-55-7
PubChem ID 3086514
InChI Key NIBVEFRJDFVQLM-UHFFFAOYSA-N
Smiles Cl.OC(CCCN1CCN(CC1)C1=NC=C(F)C=N1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.49 100
ethanol 3.85 10
water 9.62 25

Preparing Stock Solutions

The following data is based on the product molecular weight 384.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 12.99 mL 25.98 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Taylor et al (1993) A role for sigma binding in the antipsychotic profile of BMY 14802? NIDA Res.Monogr. 133 125 PMID: 8232511

Yevich et al (1992) Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J.Med.Chem. 35 4516 PMID: 1361578

Zhang et al (1993) Further characterization of the effects of BMY 14802 on dopamine neuronal activity. Synapse 15 276 PMID: 7908761


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Keywords: BMY 14802 hydrochloride, supplier, σ, sigma, antagonists, Antipsychotic, agent, General, Receptors, BMY14802, Sigma-Related, Sigma-Related, Tocris Bioscience

1 Citation for BMY 14802 hydrochloride

Citations are publications that use Tocris products. Selected citations for BMY 14802 hydrochloride include:

Paquette et al (2008) σ ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Reprod Biol Endocrinol 19 111 PMID: 18281903


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