BMS 605541

Discontinued Product

BMS 605541 (Cat. No. 6069) has been withdrawn from sale for commercial reasons.
Description: Potent VEGFR-2 inhibitor
Chemical Name: N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Pathways (1)

Biological Activity for BMS 605541

BMS 605541 is a potent ATP-competitive VEGFR-2 inhibitor (IC50 = 23 nM). Shows >10-fold selectivity for VEGFR-2 over VEGFR-1. Displays antitumor properties in human lung and colon tumor xenograft models. Orally bioavailable in rodents.

Technical Data for BMS 605541

M. Wt 401.43
Formula C19H17F2N5OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 639858-32-5
PubChem ID 11632737
InChI Key CUPLTRAPYIXFAX-UHFFFAOYSA-N
Smiles FC1=C(NCC2=CN=C(NC3=NC=CC=C3)S2)C=C(C(NC4CC4)=O)C(F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for BMS 605541

References are publications that support the biological activity of the product.

Borzilleri et al (2006) Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J.Med.Chem 49 3766 PMID: 16789733

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Keywords: BMS 605541, BMS 605541 supplier, BMS605541, VEFGR-2, inhibitors, inhibits, antitumor, VEGFR, 6069, Tocris Bioscience

Citations for BMS 605541

Citations are publications that use Tocris products.

Currently there are no citations for BMS 605541.

Reviews for BMS 605541

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for BMS 605541

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.