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Submit ReviewBMS 605541
Description: Potent VEGFR-2 inhibitor
Chemical Name: N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide
Purity: ≥98% (HPLC)
Biological Activity for BMS 605541
BMS 605541 is a potent ATP-competitive VEGFR-2 inhibitor (IC50 = 23 nM). Shows >10-fold selectivity for VEGFR-2 over VEGFR-1. Displays antitumor properties in human lung and colon tumor xenograft models. Orally bioavailable in rodents.
Technical Data for BMS 605541
| M. Wt | 401.43 |
| Formula | C19H17F2N5OS |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 639858-32-5 |
| PubChem ID | 11632737 |
| InChI Key | CUPLTRAPYIXFAX-UHFFFAOYSA-N |
| Smiles | FC1=C(NCC2=CN=C(NC3=NC=CC=C3)S2)C=C(C(NC4CC4)=O)C(F)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BMS 605541
References for BMS 605541
References are publications that support the biological activity of the product.
Borzilleri et al (2006) Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J.Med.Chem 49 3766 PMID: 16789733
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Keywords: BMS 605541, BMS 605541 supplier, BMS605541, VEFGR-2, inhibitors, inhibits, antitumor, VEGFR, 6069, Tocris Bioscience
Citations for BMS 605541
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Currently there are no citations for BMS 605541.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Pathways for BMS 605541
