BMS 566419

Pricing Availability Delivery Time Qty
Cat.No. 5492 - BMS 566419 | C28H30FN5O2 | CAS No. 566161-24-8
Description: Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Chemical Name: N-[1-[6-(4-Ethyl-1-piperazinyl)-3-pyridinyl]-1-methylethyl]-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.

Compound Libraries

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Technical Data

M. Wt 487.57
Formula C28H30FN5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 566161-24-8
PubChem ID 9913339
InChI Key XEVJUIZOZCFECP-UHFFFAOYSA-N
Smiles O=C2C3=C(C=C(C(NC(C)(C)C4=CC=C(N5CCN(CC)CC5)N=C4)=O)C(F)=C3)NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 24.38 50
DMSO 48.76 100

Preparing Stock Solutions

The following data is based on the product molecular weight 487.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.25 mL 20.51 mL
5 mM 0.41 mL 2.05 mL 4.1 mL
10 mM 0.21 mL 1.03 mL 2.05 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Watterson et al (2007) Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 50 3730 PMID: 17585753


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Keywords: BMS566419 inosine monophosphate dehydrogenase inhibitors inhibits IMPDH immunosuppressant anti-inflammatory rheumatoid arthritis orally available potent Other Dehydrogenases

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