BMS 566419

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Chemical Name: N-[1-[6-(4-Ethyl-1-piperazinyl)-3-pyridinyl]-1-methylethyl]-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for BMS 566419

BMS 566419 is a potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.

Technical Data for BMS 566419

M. Wt 487.57
Formula C28H30FN5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 566161-24-8
PubChem ID 9913339
InChI Key XEVJUIZOZCFECP-UHFFFAOYSA-N
Smiles O=C2C3=C(C=C(C(NC(C)(C)C4=CC=C(N5CCN(CC)CC5)N=C4)=O)C(F)=C3)NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 566419

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 24.38 50
DMSO 48.76 100

Preparing Stock Solutions for BMS 566419

The following data is based on the product molecular weight 487.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.25 mL 20.51 mL
5 mM 0.41 mL 2.05 mL 4.1 mL
10 mM 0.21 mL 1.03 mL 2.05 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for BMS 566419

References are publications that support the biological activity of the product.

Watterson et al (2007) Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 50 3730 PMID: 17585753


If you know of a relevant reference for BMS 566419, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Dehydrogenase Inhibitors

Keywords: BMS 566419, BMS 566419 supplier, BMS566419, inosine, monophosphate, dehydrogenase, inhibitors, inhibits, IMPDH, immunosuppressant, anti-inflammatory, rheumatoid, arthritis, orally, available, potent, Other, Dehydrogenases, 5492, Tocris Bioscience

Citations for BMS 566419

Citations are publications that use Tocris products.

Currently there are no citations for BMS 566419. Do you know of a great paper that uses BMS 566419 from Tocris? Please let us know.

Reviews for BMS 566419

There are currently no reviews for this product. Be the first to review BMS 566419 and earn rewards!

Have you used BMS 566419?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.