BMS 214662

Discontinued Product

BMS 214662 (Cat. No. 1444) has been withdrawn from sale for commercial reasons.
Cat.No. 1444 - BMS 214662 | CAS No. 195987-41-8
Description: Potent and selective farnesyl transferase inhibitor
Chemical Name: (3R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity

Potent and selective farnesyl transferase inhibitor (IC50 = 1.35 nM). 1000-fold selective over GGT1 enzyme. Exhibits anti-tumour activity in vivo following oral administration.

Licensing Information

Sold with the permission of Bristol-Myers Squibb Company, subject to U.S. Patent No. 6,011,029 and other US and foreign patents.

Technical Data

M. Wt 489.61
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 195987-41-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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References are publications that support the biological activity of the product.

Hunt et al (2000) Discovery of (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumour activity. J.Med.Chem. 43 3587 PMID: 11020273

Owa et al (2001) Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. Curr.Med.Chem. 8 1487 PMID: 11562278

Rose et al (2001) Preclinical antitumour activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res. 61 7507 PMID: 11606387

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Keywords: BMS 214662, BMS 214662 supplier, Other, Transferases, Post-translational, Modifications, 1444, Tocris Bioscience

Citations for BMS 214662

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