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Submit ReviewBMS 214662
Discontinued Product
BMS 214662 (Cat. No. 1444) has been withdrawn from sale for commercial reasons.
Description: Potent and selective farnesyl transferase inhibitor
Chemical Name: (3R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile
Purity: ≥99% (HPLC)
Biological Activity for BMS 214662
Potent and selective farnesyl transferase inhibitor (IC50 = 1.35 nM). 1000-fold selective over GGT1 enzyme. Exhibits anti-tumour activity in vivo following oral administration.
Licensing Information
Sold with the permission of Bristol-Myers Squibb Company, subject to U.S. Patent No. 6,011,029 and other US and foreign patents.
Technical Data for BMS 214662
| M. Wt | 489.61 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 195987-41-8 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BMS 214662
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
Please contact Customer Service
References for BMS 214662
References are publications that support the biological activity of the product.
Hunt et al (2000) Discovery of (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumour activity. J.Med.Chem. 43 3587 PMID: 11020273
Owa et al (2001) Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. Curr.Med.Chem. 8 1487 PMID: 11562278
Rose et al (2001) Preclinical antitumour activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res. 61 7507 PMID: 11606387
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Keywords: BMS 214662, BMS 214662 supplier, Other, Transferases, Post-translational, Modifications, 1444, Tocris Bioscience
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