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Cat.No. 5375 - BIX | C9H7NO3S | CAS No. 101714-41-4
Description: BiP (Hsp70-5) ER chaperone inducer
Chemical Name: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity

BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo.

Technical Data

M. Wt 209.22
Formula C9H7NO3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 101714-41-4
PubChem ID 16656807
Smiles O=C(CSC#N)C1=CC=C(O)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.92 100
ethanol 20.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 209.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.78 mL 23.9 mL 47.8 mL
5 mM 0.96 mL 4.78 mL 9.56 mL
10 mM 0.48 mL 2.39 mL 4.78 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

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References are publications that support the biological activity of the product.

Inokuchi et al (2009) Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest.Ophthalmol.Vis.Sci. 50 334 PMID: 18757512

Oida et al (2008) Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 1208 217 PMID: 18395193

Kudo et al (2008) A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 15 364 PMID: 18049481

If you know of a relevant reference for BIX, please let us know.

Keywords: BIX, BIX supplier, BIP, ER, endoplasmic, reticulum, chaperones, inducers, stress, binding, immunoglobulin, protein, Hsp70, Other, stress/UPR, 5375, Tocris Bioscience

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