BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 209.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.78 mL||23.9 mL||47.8 mL|
|5 mM||0.96 mL||4.78 mL||9.56 mL|
|10 mM||0.48 mL||2.39 mL||4.78 mL|
|50 mM||0.1 mL||0.48 mL||0.96 mL|
References are publications that support the biological activity of the product.
Inokuchi et al (2009) Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest.Ophthalmol.Vis.Sci. 50 334 PMID: 18757512
Oida et al (2008) Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 1208 217 PMID: 18395193
Kudo et al (2008) A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 15 364 PMID: 18049481
If you know of a relevant reference for BIX, please let us know.
View Related Products by Target
Keywords: BIX, BIX supplier, BIP, ER, endoplasmic, reticulum, chaperones, inducers, stress, binding, immunoglobulin, protein, Hsp70, Other, stress/UPR, 5375, Tocris Bioscience
Citations for BIX
Citations are publications that use Tocris products.
Currently there are no citations for BIX. Do you know of a great paper that uses BIX from Tocris? Please let us know.
Reviews for BIX
There are currently no reviews for this product. Be the first to review BIX and earn rewards!
Have you used BIX?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.