BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 209.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.78 mL||23.9 mL||47.8 mL|
|5 mM||0.96 mL||4.78 mL||9.56 mL|
|10 mM||0.48 mL||2.39 mL||4.78 mL|
|50 mM||0.1 mL||0.48 mL||0.96 mL|
References are publications that support the products' biological activity.
Inokuchi et al (2009) Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest.Ophthalmol.Vis.Sci. 50 334 PMID: 18757512
Oida et al (2008) Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 1208 217 PMID: 18395193
Kudo et al (2008) A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 15 364 PMID: 18049481
If you know of a relevant reference for BIX, please let us know.
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Keywords: BIX, supplier, BIP, ER, endoplasmic, reticulum, chaperones, inducers, stress, binding, immunoglobulin, protein, Hsp70, Other, ER, stress/UPR, Hsp70, Tocris Bioscience
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