BIX NHE1 inhibitor

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Description: Potent and selective NHE1 inhibitor
Chemical Name: 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for BIX NHE1 inhibitor

BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

Technical Data for BIX NHE1 inhibitor

M. Wt 392.8
Formula C16H19F3N4O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1422252-46-7
PubChem ID 121513866
Smiles CC(N(CC2)CCC2C1=C(C(F)(F)F)C=C(C(NC(N)=N)=O)C=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BIX NHE1 inhibitor

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.64 50

Preparing Stock Solutions for BIX NHE1 inhibitor

The following data is based on the product molecular weight 392.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.09 mL 25.46 mL 50.92 mL
2.5 mM 1.02 mL 5.09 mL 10.18 mL
5 mM 0.51 mL 2.55 mL 5.09 mL
25 mM 0.1 mL 0.51 mL 1.02 mL

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Product Datasheets for BIX NHE1 inhibitor

References for BIX NHE1 inhibitor

References are publications that support the biological activity of the product.

Kilić et al (2014) Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation. J.Pharmacol.Exp.Ther. 351 492 PMID: 25216745

Huber et al (2012) Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J.Med.Chem. 55 7114 PMID: 22803959

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1 Citation for BIX NHE1 inhibitor

Citations are publications that use Tocris products. Selected citations for BIX NHE1 inhibitor include:

Valerie M et al (2021) Adhesion-mediated mechanosignaling forces mitohormesis. Cell Metab 33 1322-1341.e13 PMID: 34019840

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Literature in this Area

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