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Submit ReviewBiperiden hydrochloride
Description: Muscarinic receptor antagonist; some selectivity for M1
Alternative Names: Akineton
Chemical Name: α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidinepropanol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Biperiden hydrochloride
Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.
Technical Data for Biperiden hydrochloride
| M. Wt | 347.92 |
| Formula | C21H29NO.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1235-82-1 |
| PubChem ID | 92151 |
| InChI Key | RDNLAULGBSQZMP-UHFFFAOYSA-N |
| Smiles | OC(CCN3CCCCC3)(C4=CC=CC=C4)C1CC2C=CC1C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Biperiden hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.74 | 5 | |
| DMSO | 3.48 | 10 |
Preparing Stock Solutions for Biperiden hydrochloride
The following data is based on the product molecular weight 347.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.74 mL | 143.71 mL | 287.42 mL |
| 0.5 mM | 5.75 mL | 28.74 mL | 57.48 mL |
| 1 mM | 2.87 mL | 14.37 mL | 28.74 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.75 mL |
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Product Datasheets for Biperiden hydrochloride
References for Biperiden hydrochloride
References are publications that support the biological activity of the product.
Bolden et al (1992) Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 260 576 PMID: 1346637
Sudo et al (1999) Muscarinic receptor occupancy by bipe. in living human brain. Life Sci. 64 PL99 PMID: 10069534
Brocks (1999) Anticholinergic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective. J.Pharm.Pharmaceut.Sci. 2 39
If you know of a relevant reference for Biperiden hydrochloride, please let us know.
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Keywords: Biperiden hydrochloride, Biperiden hydrochloride supplier, Muscarinic, receptor, antagonists, selectivity, M1, Receptors, Acetylcholine, ACh, Akineton, 2853, Tocris Bioscience
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