Muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 347.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.87 mL||14.37 mL||28.74 mL|
|5 mM||0.57 mL||2.87 mL||5.75 mL|
|10 mM||0.29 mL||1.44 mL||2.87 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
References are publications that support the products' biological activity.
Bolden et al (1992) Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 260 576 PMID: 1346637
Sudo et al (1999) Muscarinic receptor occupancy by biperiden in living human brain. Life Sci. 64 PL99 PMID: 10069534
If you know of a relevant reference for Biperiden hydrochloride, please let us know.
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Keywords: Biperiden hydrochloride, supplier, Muscarinic, receptor, antagonists, selectivity, M1, Receptors, Acetylcholine, ACh, Akineton, M1, Receptors, M1, Receptors, Tocris Bioscience
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