BIM 23042

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Cat.No. 3237 - BIM 23042 | D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH2 | CAS No. 111857-96-6
Description: Selective neuromedin B receptor antagonist (NMB-R, BB1)
Datasheet
Citations (1)
Literature

Biological Activity

Selective neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 216 and 18,264 nM for BB1 and BB2 receptors respectively). Displays no activity at a range of other receptors.

Technical Data

M. Wt 1192.46
Formula C63H73N11O9S2
Sequence XCYWKVCX

(Modifications: Disulfide bridge between 2 - 7, X-1 = D-Nal, Trp-4 = D-Trp, X-8 = Nal & C-terminal amide)

Storage Desiccate at -20°C
CAS Number 111857-96-6
PubChem ID 16173213
InChI Key WASLGBPOQJKRMS-AAFDAGAGSA-N
Smiles [H]N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 0.1% acetic acid

Preparing Stock Solutions

The following data is based on the product molecular weight 1192.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.84 mL 4.19 mL 8.39 mL
5 mM 0.17 mL 0.84 mL 1.68 mL
10 mM 0.08 mL 0.42 mL 0.84 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Orbuch et al (1993) Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Mol.Pharmacol. 44 841 PMID: 7901752

Ryan et al (1996) Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur.J.Pharmacol. 306 307 PMID: 8813645

Milusheva et al (1998) Role of different bombesin receptor subtypes mediating contractile activity in cat upper gastrointestinal tract. Peptides 19 549 PMID: 9533644


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Keywords: BIM 23042, supplier, Selective, neuromedin, B, receptor, antagonists, NMB-R, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23042, Bombesin, Receptors, Tocris Bioscience

1 Citation for BIM 23042

Citations are publications that use Tocris products. Selected citations for BIM 23042 include:

Blais et al (2016) Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin Neuroscience Letters 633 262 PMID: 27693662


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