BIM 23042

Pricing Availability   Qty
Cat.No. 3237 - BIM 23042 | D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH2 | CAS No. 111857-96-6
Description: Selective neuromedin B receptor antagonist (NMB-R, BB1)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 216 and 18,264 nM for BB1 and BB2 receptors respectively). Displays no activity at a range of other receptors.

Technical Data

M. Wt 1192.46
Formula C63H73N11O9S2
Sequence XCYWKVCX

(Modifications: Disulfide bridge between 2 - 7, X-1 = D-Nal, Trp-4 = D-Trp, X-8 = Nal & C-terminal amide)

Storage Desiccate at -20°C
CAS Number 111857-96-6
PubChem ID 16173213
InChI Key WASLGBPOQJKRMS-AAFDAGAGSA-N
Smiles [H]N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in 0.1% acetic acid

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Orbuch et al (1993) Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Mol.Pharmacol. 44 841 PMID: 7901752

Ryan et al (1996) Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur.J.Pharmacol. 306 307 PMID: 8813645

Milusheva et al (1998) Role of different bombesin receptor subtypes mediating contractile activity in cat upper gastrointestinal tract. Peptides 19 549 PMID: 9533644


If you know of a relevant reference for BIM 23042, please let us know.

View Related Products by Product Action

View all Bombesin Receptor Antagonists

Keywords: BIM 23042, BIM 23042 supplier, Selective, neuromedin, B, receptor, antagonists, NMB-R, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23042, Receptors, 3237, Tocris Bioscience

1 Citation for BIM 23042

Citations are publications that use Tocris products. Selected citations for BIM 23042 include:

Blais et al (2016) Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin Neuroscience Letters 633 262 PMID: 27693662


Do you know of a great paper that uses BIM 23042 from Tocris? Please let us know.

Reviews for BIM 23042

There are currently no reviews for this product. Be the first to review BIM 23042 and earn rewards!

Have you used BIM 23042?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.