BIM 189

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Cat.No. 2717 - BIM 189 | D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-(4-Cl)Phe-NH2 | CAS No. 142062-55-3
Description: Bombesin antagonist
Alternative Names: [D-Phe6,Leu13,Cpa14]bombesin-(6-14)NH2
Datasheet
Citations
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Literature

Biological Activity

Bombesin antagonist that reduces bombesin-induced satiety.

Technical Data

M. Wt 1137.73
Formula C56H73ClN14O10
Sequence FQWAVGHLF

(Modifications: Phe-1 = D-Phe, Phe-9 = 4-Cl-Phe & C-terminal amide)

Storage Store at -20°C
CAS Number 142062-55-3
PubChem ID 5748499
InChI Key XJWMPWLZAVKSPK-UYBYNCNQSA-N
Smiles [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(Cl)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in 20% acetonitrile

References

References are publications that support the biological activity of the product.

Coy et al (1990) Short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig acinar cells. Eur.J.Pharmacol. 190 31 PMID: 1963850

Laferrere et al (1992) Effects of bombesin, of a new bombesin agonist (BIM187) and a new antagonist (BIM189) on food intake in rats, in relation to cholecystokinin. Eur.J.Pharmacol. 215 23 PMID: 1516647


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Keywords: BIM 189, BIM 189 supplier, Bombesin, antagonists, GRP-Preferring, Receptors, BB1, BB2, BB3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, BIM189, [D-Phe6,Leu13,Cpa14]bombesin-(6-14)NH2, 2717, Tocris Bioscience

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