Bombesin antagonist that reduces bombesin-induced satiety.
(Modifications: Phe-1 = D-Phe, Phe-9 = 4-Cl-Phe & C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in 20% acetonitrile|
Preparing Stock Solutions
The following data is based on the product molecular weight 1137.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.88 mL||4.39 mL||8.79 mL|
|5 mM||0.18 mL||0.88 mL||1.76 mL|
|10 mM||0.09 mL||0.44 mL||0.88 mL|
|50 mM||0.02 mL||0.09 mL||0.18 mL|
References are publications that support the products' biological activity.
Coy et al (1990) Short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig acinar cells. Eur.J.Pharmacol. 190 31 PMID: 1963850
Laferrere et al (1992) Effects of bombesin, of a new bombesin agonist (BIM187) and a new antagonist (BIM189) on food intake in rats, in relation to cholecystokinin. Eur.J.Pharmacol. 215 23 PMID: 1516647
If you know of a relevant reference for BIM 189, please let us know.
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Keywords: BIM 189, supplier, Bombesin, antagonists, GRP-Preferring, Receptors, BB1, BB2, BB3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, BIM189, [D-Phe6,Leu13,Cpa14]bombesin-(6-14)NH2, Bombesin, Receptors, Bombesin, Receptors, Tocris Bioscience
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.