BIM 189

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Cat.No. 2717 - BIM 189 | D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-(4-Cl)Phe-NH2 | CAS No. 142062-55-3
Description: Bombesin antagonist
Alternative Names: [D-Phe6,Leu13,Cpa14]bombesin-(6-14)NH2
Datasheet
Citations
Literature

Biological Activity

Bombesin antagonist that reduces bombesin-induced satiety.

Technical Data

M. Wt 1137.73
Formula C56H73ClN14O10
Sequence FQWAVGHLF

(Modifications: Phe-1 = D-Phe, Phe-9 = 4-Cl-Phe & C-terminal amide)

Storage Store at -20°C
CAS Number 142062-55-3
PubChem ID 5748499
InChI Key XJWMPWLZAVKSPK-UYBYNCNQSA-N
Smiles [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(Cl)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 20% acetonitrile

Preparing Stock Solutions

The following data is based on the product molecular weight 1137.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.88 mL 4.39 mL 8.79 mL
5 mM 0.18 mL 0.88 mL 1.76 mL
10 mM 0.09 mL 0.44 mL 0.88 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Coy et al (1990) Short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig acinar cells. Eur.J.Pharmacol. 190 31 PMID: 1963850

Laferrere et al (1992) Effects of bombesin, of a new bombesin agonist (BIM187) and a new antagonist (BIM189) on food intake in rats, in relation to cholecystokinin. Eur.J.Pharmacol. 215 23 PMID: 1516647


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Keywords: Bombesin antagonists GRP-Preferring Receptors BB1 BB2 BB3 Gastrin-Releasing Peptide-Preferring NMB-Preferring Neuromedin B-Preferring BIM189 [D-Phe6,Leu13,Cpa14]bombesin-(6-14)NH2 Bombesin Receptors

Citations for BIM 189

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