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Biological Activity for BIIB 021
BIIB 021 is a selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.
Compound Libraries for BIIB 021
Technical Data for BIIB 021
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BIIB 021
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BIIB 021
The following data is based on the product molecular weight 318.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.14 mL||15.69 mL||31.37 mL|
|5 mM||0.63 mL||3.14 mL||6.27 mL|
|10 mM||0.31 mL||1.57 mL||3.14 mL|
|50 mM||0.06 mL||0.31 mL||0.63 mL|
References for BIIB 021
References are publications that support the biological activity of the product.
Lundgren et al (2009) BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol.Cancer Ther. 8 921 PMID: 19372565
Yin et al (2010) BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int.J.Cancer 126 1216 PMID: 19662650
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Citations for BIIB 021
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Reviews for BIIB 021
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Human osteosarcoma, U2OS, cells were treated with BIIB 021 (1 microM) for 24 h to follow PARP cleavage using Western blot. BIIB 021 activated PARP cleavage in U2OS cells
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