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Submit ReviewBigLEN (rat)
Discontinued Product
BigLEN (rat) (Cat. No. 6306) has been withdrawn from sale for commercial reasons.
Description: Potent GPR171 agonist
Biological Activity for BigLEN (rat)
Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.
Technical Data for BigLEN (rat)
| M. Wt | 1746 |
| Formula | C76H128N24O23 |
| Sequence | LENSSPQAPARRLLPP |
| Storage | Store at -20°C |
| CAS Number | 369377-66-2 |
| PubChem ID | 131648251 |
| InChI Key | IPOOBASOJFKEAK-GTJGPZIJSA-N |
| Smiles | [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BigLEN (rat)
References for BigLEN (rat)
References are publications that support the biological activity of the product.
Gomes et al (2013) GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc.Natl.Acad.Sci.USA. 110 16211 PMID: 24043826
Mack et al (2019) Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation. ACS Chem.Neurosci. 10 1884 PMID: 30726666
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Keywords: BigLEN (rat), BigLEN (rat) supplier, agonists, agonism, GPR171, body, weight, neurite, outgrowth, 6306, Tocris Bioscience
Citations for BigLEN (rat)
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Currently there are no citations for BigLEN (rat).
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