BigLEN (rat)

Pricing Availability Delivery Time Qty
Cat.No. 6306 - BigLEN (rat) | Leu-Glu-Asn-Ser-Ser-Pro-Gln-Ala-Pro-Ala-Arg-Arg-Leu-Leu-Pro-Pro | CAS No. 369377-66-2
Description: Potent GPR171 agonist
Datasheet
Citations
Literature

Biological Activity

Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.

Technical Data

M. Wt 1746
Formula C76H128N24O23
Sequence LENSSPQAPARRLLPP
Storage Store at -20°C
CAS Number 369377-66-2
InChI Key IPOOBASOJFKEAK-UVZUZSPBNA-N
Smiles [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1746. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.57 mL 2.86 mL 5.73 mL
5 mM 0.11 mL 0.57 mL 1.15 mL
10 mM 0.06 mL 0.29 mL 0.57 mL
50 mM 0.01 mL 0.06 mL 0.11 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gomes et al (2013) GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc.Natl.Acad.Sci.USA. 110 16211 PMID: 24043826


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Keywords: BigLEN (rat), supplier, agonists, agonism, GPR171, body, weight, neurite, outgrowth, GPR171, GPR171, Tocris Bioscience

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