Bicalutamide

Pricing Availability Delivery Time Qty
Cat.No. 3389 - Bicalutamide | C18H14F4N2O4S | CAS No. 90357-06-5
Description: Non-steroidal androgen receptor antagonist
Alternative Names: Casodex, ICI 176,334
Chemical Name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Orally active non-steroidal androgen receptor antagonist (IC50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo.

Licensing Information

Sold for research purposes only under agreement from AstraZeneca

Compound Libraries

Bicalutamide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 430.37
Formula C18H14F4N2O4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 90357-06-5
PubChem ID 2375
InChI Key LKJPYSCBVHEWIU-UHFFFAOYSA-N
Smiles O=C(C(O)(C)CS(C2=CC=C(F)C=C2)(=O)=O)NC1=CC(C(F)(F)F)=C(C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.04 100
ethanol 4.3 10

Preparing Stock Solutions

The following data is based on the product molecular weight 430.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.62 mL 23.24 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Furr et al (1987) ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen. J.Endocrinol. 113 R7 PMID: 3625091

Tucker et al (1988) Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides. J.Med.Chem. 31 954 PMID: 3361581

Furr and Tucker (1996) The preclinical development of bicalutamide: pharmacodynamics and mechanism of action. Urology 47 13 PMID: 8560673


If you know of a relevant reference for Bicalutamide, please let us know.

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Keywords: Bicalutamide, supplier, Non-steroidal, Androgen, receptor, antagonists, Dihydrotestosterone, Receptors, AstraZeneca, ICI176,334, chemotherapeutics, Casodex, ICI, 176,334, Androgen, Receptor, Androgen, Receptor, Tocris Bioscience

3 Citations for Bicalutamide

Citations are publications that use Tocris products. Selected citations for Bicalutamide include:

Ivachtchenko et al (2014) Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment. PLoS One 5 133 PMID: 24494031

Ishizaki et al (2013) Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer. Sci Rep 3 1528 PMID: 23524847

Gambara et al (2015) TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo. J Cell Mol Med 19 327 PMID: 25444175


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