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Hepatocyte nuclear factor 4α (HNF4α) antagonist. Represses expression of known HNF4α target genes. Decreases HNF4α DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 331.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||15.09 mL||75.45 mL||150.9 mL|
|1 mM||3.02 mL||15.09 mL||30.18 mL|
|2 mM||1.51 mL||7.54 mL||15.09 mL|
|10 mM||0.3 mL||1.51 mL||3.02 mL|
References are publications that support the biological activity of the product.
Kiselyuk et al (2012) HNF4α antagonists discovered by a high-throughput screen for modulators of the human Ins promoter. Chem.Biol. 19 806 PMID: 22840769
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Keywords: BI 6015, BI 6015 supplier, BI6015, Hepatocyte, nuclear, factor, 4, alpha, HNF4a, HNF4α, antagonists, DNA, binding, cancer, Other, Transcription, Factors, 4641, Tocris Bioscience
2 Citations for BI 6015
Citations are publications that use Tocris products. Selected citations for BI 6015 include:
Hu et al (2018) Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma. Front Pharmacol 9 1150 PMID: 30405404
Levy et al (2016) Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection Nature Chemical Biology 12 1037 PMID: 27723751
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