BI 6015

Pricing Availability Delivery Time Qty
Cat.No. 4641 - BI 6015 | C15H13N3O4S | CAS No. 93987-29-2
Description: Hepatocyte nuclear factor 4α (HNF4α) antagonist
Chemical Name: 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Hepatocyte nuclear factor 4α (HNF4α) antagonist. Represses expression of known HNF4α target genes. Decreases HNF4α DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.

Technical Data

M. Wt 331.35
Formula C15H13N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 93987-29-2
PubChem ID 3269393
InChI Key ILVCPQPMRPHZSG-UHFFFAOYSA-N
Smiles CC2=NC1=CC=CC=C1N2S(C3=C(C)C=CC([N+]([O-])=O)=C3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.63 20
ethanol 1.66 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 331.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.09 mL 30.18 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kiselyuk et al (2012) HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem.Biol. 19 806 PMID: 22840769


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Keywords: BI6015 Hepatocyte nuclear factor 4 alpha HNF4a HNF4α antagonists DNA binding cancer Other Transcription Factors

1 Citation for BI 6015

Citations are publications that use Tocris products. Selected citations for BI 6015 include:

Levy et al (2016) Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection Nature Chemical Biology 12 1037 PMID: 27723751


Do you know of a great paper that uses BI 6015 from Tocris? If so please let us know.

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for BI 6015

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