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Potent and selective inhibitor of human SLC13A5 (Na+/citrate cotransporter; IC50 = 56 nM in HEK cells overexpressing hSLC13A5 and 24 nM in HepG2 cells with endogenous SLC13A5 expression). Displays >1000-fold selectivity over other family members.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI01383298 probe summary on the SGC website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 445.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.49 mL||22.45 mL||44.91 mL|
|2.5 mM||0.9 mL||4.49 mL||8.98 mL|
|5 mM||0.45 mL||2.25 mL||4.49 mL|
|25 mM||0.09 mL||0.45 mL||0.9 mL|
References are publications that support the biological activity of the product.
Peters (2017) Flipping a citrate switch on liver cancer cells. J.Biol.Chem. 292 13902 PMID: 28821606
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Keywords: BI 01383298, BI 01383298 supplier, BI01383298, SLC13A5, inhibitors, inhibits, sodium, citrate, cotransporter, contransport, NaCT, NACT, INDY, Other, Ion, Pumps/Transporters, 6518, Tocris Bioscience
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