BGC 20-1531 hydrochloride

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Cat.No. 5327 - BGC 20-1531 hydrochloride | C26H24N2O6S.HCl
Description: High affinity and selective EP4 antagonist
Alternative Names: PGN 1531
Chemical Name: 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.

Technical Data

M. Wt 529
Formula C26H24N2O6S.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 121513858
InChI Key ZSHYZCXOFPPBMH-UHFFFAOYSA-N
Smiles CC(OC(C(NS(C4=CC=CC=C4C)(=O)=O)=O)=C3)=C3COC(C=C2)=CC=C2C1=NC=C(OC)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 529. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.45 mL 18.9 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sutton et al (2014) From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor. Bioorg.Med.Chem.Lett. 24 2212 PMID: 24703233


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Citations for BGC 20-1531 hydrochloride

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