BGC 20-1531 hydrochloride

Pricing Availability   Qty
Description: High affinity and selective EP4 antagonist
Alternative Names: PGN 1531
Chemical Name: 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for BGC 20-1531 hydrochloride

BGC 20-1531 hydrochloride is a high affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.

Compound Libraries for BGC 20-1531 hydrochloride

BGC 20-1531 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BGC 20-1531 hydrochloride

M. Wt 529
Formula C26H24N2O6S.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1962928-26-2
PubChem ID 121513858
InChI Key ZSHYZCXOFPPBMH-UHFFFAOYSA-N
Smiles CC(OC(C(NS(C4=CC=CC=C4C)(=O)=O)=O)=C3)=C3COC(C=C2)=CC=C2C1=NC=C(OC)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BGC 20-1531 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.25 100

Preparing Stock Solutions for BGC 20-1531 hydrochloride

The following data is based on the product molecular weight 529. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.45 mL 18.9 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for BGC 20-1531 hydrochloride

References for BGC 20-1531 hydrochloride

References are publications that support the biological activity of the product.

Sutton et al (2014) From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor. Bioorg.Med.Chem.Lett. 24 2212 PMID: 24703233


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2 Citations for BGC 20-1531 hydrochloride

Citations are publications that use Tocris products. Selected citations for BGC 20-1531 hydrochloride include:

Perkins et al (2018) Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat.Immunol. 19 1309 PMID: 30397349

David et al (2022) Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer. Cancer Discov 12 1904-1921 PMID: 35552618


Do you know of a great paper that uses BGC 20-1531 hydrochloride from Tocris? Please let us know.

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