Beraprost sodium

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Description: Potent prostacyclin IP receptor agonist
Chemical Name: rel-(1R,2R,3aS,8bS)-2,3,3a,8b-Tetrahydro-2-hydroxy-1-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid sodium salt
Purity: ≥98% (HPLC)

Biological Activity for Beraprost sodium

Beraprost sodium is a potent IP receptor agonist; analog of Epoprostenol (Cat. No. 2989). Potently inhibits ADP-induced platelet aggregation and P-selectin expression in vitro (pIC50 values are 8.26 and 8.56, respectively). Also increases vasodilation and reduces pulmonary hypertension in vivo. Orally active.

Technical Data for Beraprost sodium

M. Wt 420.47
Formula C24H29NaO5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 496807-11-5
PubChem ID 23663404
Smiles O[C@@H]1C[C@H]2[C@H](C(C=CC=C3CCCC(O[Na])=O)=C3O2)[C@H]1/C=C/[C@@H](O)C(C)CC#CC.O[C@H]4C[C@@H]5[C@@H](C(C=CC=C6CCCC(O[Na])=O)=C6O5)[C@@H]4/C=C/[C@H](O)C(C)CC#CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Beraprost sodium

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 10.51 25

Preparing Stock Solutions for Beraprost sodium

The following data is based on the product molecular weight 420.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.51 mL 47.57 mL 95.13 mL
1.25 mM 1.9 mL 9.51 mL 19.03 mL
2.5 mM 0.95 mL 4.76 mL 9.51 mL
12.5 mM 0.19 mL 0.95 mL 1.9 mL

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Product Datasheets for Beraprost sodium

Certificate of Analysis / Product Datasheet
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References for Beraprost sodium

References are publications that support the biological activity of the product.

Miyamoto et al (2003) Effects of TRA-418, a novel TP-receptor antagonist, and IP-receptor agonist, on human platelet activation and aggregation. Br.J.Pharmacol. 140 889 PMID: 14504133

Saito et al (1995) Effects of beraprost sodium (a PGI2 derivative) on chronic hypoxic pulmonary hypertension in the rat. Nihon Kyobu Shikkan Gakkai Zasshi. 33 497 PMID: 7609334

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Keywords: Beraprost sodium, Beraprost sodium supplier, Prostacyclin, IP, receptor, agonists, pulmonary, hypertension, vasodilation, platelet, aggregation, 88475-69-8, Prostanoid, Receptors, 4180, Tocris Bioscience

Citations for Beraprost sodium

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