Beraprost sodium

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Cat.No. 4180 - Beraprost sodium | C24H29NaO5 | CAS No. 88475-69-8
Description: Potent prostacyclin IP receptor agonist
Chemical Name: 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent IP receptor agonist; analog of Epoprostenol (Cat. No. 2989). Potently inhibits ADP-induced platelet aggregation and P-selectin expression in vitro (pIC50 values are 8.26 and 8.56, respectively). Also increases vasodilation and reduces pulmonary hypertension in vivo. Orally active.

Technical Data

M. Wt 420.47
Formula C24H29NaO5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 88475-69-8
PubChem ID 23663404
InChI Key YTCZZXIRLARSET-VJRSQJMHSA-M
Smiles O[C@@H]1C[C@H]2[C@H]([C@@](C=CC=C3CCCC(O[Na])=O)=C3O2)[C@H]1/C=C/[C@@H](O)C(C)CC#CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.51 25

Preparing Stock Solutions

The following data is based on the product molecular weight 420.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Miyamoto et al (2003) Effects of TRA-418, a novel TP-receptor antagonist, and IP-receptor agonist, on human platelet activation and aggregation. Br.J.Pharmacol. 140 889 PMID: 14504133

Saito et al (1995) Effects of beraprost sodium (a PGI2 derivative) on chronic hypoxic pulmonary hypertension in the rat. Nihon Kyobu Shikkan Gakkai Zasshi. 33 497 PMID: 7609334


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Keywords: Prostacyclin IP receptor agonists pulmonary hypertension vasodilation platelet aggregation Prostanoid Receptors

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