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Biological Activity for Beraprost sodium
Beraprost sodium is a potent IP receptor agonist; analog of Epoprostenol (Cat. No. 2989). Potently inhibits ADP-induced platelet aggregation and P-selectin expression in vitro (pIC50 values are 8.26 and 8.56, respectively). Also increases vasodilation and reduces pulmonary hypertension in vivo. Orally active.
Technical Data for Beraprost sodium
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Beraprost sodium
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Beraprost sodium
The following data is based on the product molecular weight 420.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||9.51 mL||47.57 mL||95.13 mL|
|1.25 mM||1.9 mL||9.51 mL||19.03 mL|
|2.5 mM||0.95 mL||4.76 mL||9.51 mL|
|12.5 mM||0.19 mL||0.95 mL||1.9 mL|
Product Datasheets for Beraprost sodium
References for Beraprost sodium
References are publications that support the biological activity of the product.
Miyamoto et al (2003) Effects of TRA-418, a novel TP-receptor antagonist, and IP-receptor agonist, on human platelet activation and aggregation. Br.J.Pharmacol. 140 889 PMID: 14504133
Saito et al (1995) Effects of beraprost sodium (a PGI2 derivative) on chronic hypoxic pulmonary hypertension in the rat. Nihon Kyobu Shikkan Gakkai Zasshi. 33 497 PMID: 7609334
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Citations for Beraprost sodium
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.