Epoprostenol

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Cat.No. 2989 - Epoprostenol | C20H31NaO5 | CAS No. 61849-14-7
Description: Endogenous IP receptor agonist
Alternative Names: Prostaglandin I2, Prostacyclin
Chemical Name: (5Z,13E,8R,9S,11R,12R,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Endogenous prostanoid that is a potent agonist at IP prostanoid receptors. Inhibits platelet aggregation and induces vasodilation.

Technical Data

M. Wt 374.45
Formula C20H31NaO5
Storage Desiccate at -80°C
Purity ≥99% (HPLC)
CAS Number 61849-14-7
PubChem ID 6364626
InChI Key LMHIPJMTZHDKEW-XQYLJSSYSA-M
Smiles [Na+].CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2O\C(C[C@H]12)=C/CCCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 37.44 100
DMSO 28.08 75

Preparing Stock Solutions

The following data is based on the product molecular weight 374.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.35 mL 26.71 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Kobzar et al (2001) Comparison of anti-aggregatory effects of PGI2, PGI3 and iloprost on human and rabbit platelets. Cell.Physiol.Biochem. 11 279 PMID: 11684817

Oliva and Nicosia (1987) PGI2-receptors and molecular mechanisms in platelets and vasculature: state of the art. Pharmacol.Res.Comm. 19 735


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Keywords: Epoprostenol, Epoprostenol supplier, Endogenous, IP, receptors, agonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, Prostaglandin, I2, Prostacyclin, Receptors, 2989, Tocris Bioscience

1 Citation for Epoprostenol

Citations are publications that use Tocris products. Selected citations for Epoprostenol include:

Armstrong et al (2015) Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction. Blood 126 e11 PMID: 26215112


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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