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Submit ReviewEpoprostenol
Description: Endogenous IP receptor agonist
Alternative Names: Prostaglandin I2, Prostacyclin
Chemical Name: (5Z,13E,8R,9S,11R,12R,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt
Purity: ≥99% (HPLC)
Biological Activity for Epoprostenol
Epoprostenol is an endogenous prostanoid that is a potent agonist at IP prostanoid receptors. Inhibits platelet aggregation and induces vasodilation.
Technical Data for Epoprostenol
| M. Wt | 374.45 |
| Formula | C20H31NaO5 |
| Storage | Desiccate at -80°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 61849-14-7 |
| PubChem ID | 6364626 |
| InChI Key | LMHIPJMTZHDKEW-XQYLJSSYSA-M |
| Smiles | [Na+].CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2O\C(C[C@H]12)=C/CCCC([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Epoprostenol
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 37.44 | 100 |
Preparing Stock Solutions for Epoprostenol
The following data is based on the product molecular weight 374.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.35 mL | 26.71 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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Product Datasheets for Epoprostenol
References for Epoprostenol
References are publications that support the biological activity of the product.
Kobzar et al (2001) Comparison of anti-aggregatory effects of PGI2, PGI3 and ilo. on human and rabbit platelets. Cell.Physiol.Biochem. 11 279 PMID: 11684817
Oliva and Nicosia (1987) PGI2-receptors and molecular mechanisms in platelets and vasculature: state of the art. Pharmacol.Res.Comm. 19 735
If you know of a relevant reference for Epoprostenol, please let us know.
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Keywords: Epoprostenol, Epoprostenol supplier, Endogenous, IP, receptors, agonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, Prostaglandin, I2, Prostacyclin, Receptors, 2989, Tocris Bioscience
2 Citations for Epoprostenol
Citations are publications that use Tocris products. Selected citations for Epoprostenol include:
Barwari et al (2018) Inhibition of profibrotic microRNA-21 affects platelets and their releasate. JCI Insight 3 PMID: 30385722
Armstrong et al (2015) Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction. Blood 126 e11 PMID: 26215112
Do you know of a great paper that uses Epoprostenol from Tocris? Please let us know.
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