Pricing Availability   Qty
Description: Endogenous IP receptor agonist
Alternative Names: Prostaglandin I2, Prostacyclin
Chemical Name: (5Z,13E,8R,9S,11R,12R,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for Epoprostenol

Epoprostenol is an endogenous prostanoid that is a potent agonist at IP prostanoid receptors. Inhibits platelet aggregation and induces vasodilation.

Technical Data for Epoprostenol

M. Wt 374.45
Formula C20H31NaO5
Storage Desiccate at -80°C
Purity ≥99% (HPLC)
CAS Number 61849-14-7
PubChem ID 6364626
Smiles [Na+].CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2O\C(C[C@H]12)=C/CCCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Epoprostenol

Solvent Max Conc. mg/mL Max Conc. mM
water 37.44 100

Preparing Stock Solutions for Epoprostenol

The following data is based on the product molecular weight 374.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.35 mL 26.71 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets for Epoprostenol

Certificate of Analysis / Product Datasheet
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References for Epoprostenol

References are publications that support the biological activity of the product.

Kobzar et al (2001) Comparison of anti-aggregatory effects of PGI2, PGI3 and ilo. on human and rabbit platelets. Cell.Physiol.Biochem. 11 279 PMID: 11684817

Oliva and Nicosia (1987) PGI2-receptors and molecular mechanisms in platelets and vasculature: state of the art. Pharmacol.Res.Comm. 19 735

If you know of a relevant reference for Epoprostenol, please let us know.

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Keywords: Epoprostenol, Epoprostenol supplier, Endogenous, IP, receptors, agonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, Prostaglandin, I2, Prostacyclin, Receptors, 2989, Tocris Bioscience

2 Citations for Epoprostenol

Citations are publications that use Tocris products. Selected citations for Epoprostenol include:

Barwari et al (2018) Inhibition of profibrotic microRNA-21 affects platelets and their releasate. JCI Insight 3 PMID: 30385722

Armstrong et al (2015) Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction. Blood 126 e11 PMID: 26215112

Do you know of a great paper that uses Epoprostenol from Tocris? Please let us know.

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